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Brain MRI Abnormalities in Ataxia-Telangiectasia


Habek, Mario; Brinar, Vesna; Radoš, Marko; Zadro, Ivana; Žarković, Kamelija
Brain MRI Abnormalities in Ataxia-Telangiectasia // Neurologist, 14 (2008), 192-195 doi:10.1097/NRL.0b013e31815fa5a7 (međunarodna recenzija, članak, znanstveni)


Naslov
Brain MRI Abnormalities in Ataxia-Telangiectasia

Autori
Habek, Mario ; Brinar, Vesna ; Radoš, Marko ; Zadro, Ivana ; Žarković, Kamelija

Izvornik
Neurologist (1074-7931) 14 (2008); 192-195

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ataxia-telangiectasia; magnetic resonance imaging; demyelination; age

Sažetak
Introduction: Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder, initially characterized by normal brain MRI. Case report: In a 34-year-old female patient with AT, magnetic resonance imaging (MRI) revealed extensive and diffuse white matter dismyelination, T1 and T2 hypointense lesions, T1 hypointense but T2 hyperintense lesions, and numerous dilated telangiectases upon gadolinium enhancement. Discussion: In our patient, brain MRI confirmed extensive extracerebellar lesions in AT. Conclusion: Our report broadens the spectrum of brain MRI abnormalities in AT and supports the hypothesis on cerebrovascular abnormalities occurring in later stages of AT.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )
108-1081874-1988 - Molekularne i biološke osnove demijelinizacijskih bolesti živčanog sustava (Vesna Brinar, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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