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Human metabolic databases for drug development and drug interactions

Presented is the further step in development and use of the Human Metabolism Databases created for use in drug research and development as a part of ADME Database Project. The databases are providing the latest data on specific interactions for a given substance with Human Phase I Enzymes such as P450 (CYP), FMO, AKR, MAO, and AO ; Human Phase II Enzymes such as Esterases, UGT, GST, SULT ; and more than 235 Human Transporters including ABCs, OATPs, OCTs, OATs, SLCs. The databases are supported by chemical/metabolite structures as well as kinetic values found in the literature. The databases are available online (http://life-science.fqs.fujitsu.com/admedb_en), and completely searchable by keywords or chemical structures. Advanced searches are also available to support investigations studies on drug-drug interaction.

human metabolic databases; drug development; drug interactions

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