engleski

Antimetastatic ability of honey bee products

Background and purpose: There are many reports about honey bee products, which reveal various human health promoting effects. These attributes, well-known and often-proclaimed by folk medicine, are not accepted by the healthh organisations and by science, because of insufficient scientific clinical proofs, under modern science and medical standards.We investigated the antimetastatic efficiency of water-soluble derivative of propolis (WSDP) and related polyphenolic compounds (caffeic acid-CA, caffeic acid phenethyl ester-CAPE, quercetin-QU), honey, different pollens, royal jelly (RJ), and bee venom (BV). Material and methods: Transplantable murine tumors were used: a mammary carcinoma (MCa) and a methylcholanthrene– induced fibrosarcoma (FS) of CBA mouse and an anaplastic colon adenocarcinoma (ACa) of Y59 rat. Metastases in the lung were generated by injecting viable tumor cells intravenously (iv). Results: WSDP and related polyphenolic compounds exerted a significant antimetastatic effect (p < 0.01 ; p < 0.001) when given either before or after tumor cell inoculation. A pronounced antimetastatic effect (p < 0.05) was achived by oral application of honey given before tumor cell inoculation (2 g/kg for mice or 1 g/kg for rats, once a day for 10 consecutive days) ; however given after tumor cell inoculation honey enhanced lung metastases. Some pollens (Castanea and Raphanus) given to mice orally at dose of 5% of complete daily diet before tumor cell inculation induced significant (p < 0.05) antimetastatic effect while the treatment after tumor cell inoculation was ineffective. RJ did not affect metastasis formation when given intraperitoneally (ip) or subcutaneously (sc) ; given iv prior tumor cell inoculation RJ a significantly (p < 0.05) inhibited metastasis formation. BV given to mice iv at the instant of injection of tumor cells significantly (p < 0.001) affected metastatic growth ; this was not a case with sc administration of BV. Antimetastatic effects of BV was highly depedent on route of injection and on close contact between BV and tumor cells. Conclusion:To conclude honey-bee products given orally or systemically may have an impact on tumor spread.

honey ; bee venom ; propolis ; royal jelly ; pollens ; caffei acid ; tumours ; metastasis

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