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Pregled bibliografske jedinice broj: 347750

Where to inject botulinum toxin in the treatment of pain?


Filipović, Boris; Bach-Rojecky, Lidija; Lacković Zdravko
Where to inject botulinum toxin in the treatment of pain? // 39th International Danaube Symposium ; Journal of Neural Transmission 114 ; 2007 / Riederer, Peter ; Gerlach, Manfred (ur.).
Wien, New York: Springer - Verlag, 2007. str. CXXVIII-CXXVIII (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 347750 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Where to inject botulinum toxin in the treatment of pain?

Autori
Filipović, Boris ; Bach-Rojecky, Lidija ; Lacković Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
39th International Danaube Symposium ; Journal of Neural Transmission 114 ; 2007 / Riederer, Peter ; Gerlach, Manfred - Wien, New York : Springer - Verlag, 2007, CXXVIII-CXXVIII

Skup
39th International Danaube Symposium for Neurological Sciences and Continuing Education

Mjesto i datum
Wuerzburg, Njemačka, 2-5.06.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
botulinum toxin; pain; nociception

Sažetak
Objective: Recently botulinum toxin type A (BTX-A) has been used to treat various pain syndromes. One of the intriguing and clinically important question is where to inject BTX-A. In the present study in rats we investigated: 1. whether antinociceptive effect of BTX-A is segmental and 2. if BTX-A is effective when injected into the sensory ganglia. Design and Methods. Male Wistar rats were injected into the right forepaw pad with BTX-A 7 U/kg while the second group received the same dose in the right hindpaw. Control group was injected with saline. After 5 days all groups were injected into the righ hindpaw-pad with formalin (5%). The number of flinches of the injected paw was counted over 60 min. In the second series of experiment BTX-A 0.5 U/kg was injected into the right trigeminal ganglion. Control rats received saline. After 2 days formalin (2.5%) was applied into the right upper lip. The number of seconds that the animals spent rubbing the injected area was recorded and data analysed by Newman-Keuls post hoc test. Results. BTX-A, injected into the hindpaw-pad, significantly reduced the flinches induced by formalin. Number of flinches was 280.7&#177; 9.5 for control vs. 200.6&#177; 13.7 for BTX-A (p<0.05). However, BTX-A was ineffective when injected into the right forepaw-pad (number of flinches was 260.2&#177; 31.3). Intraganglionic injection of BTX-A 0.5 U/kg significantly reduced rubbing time in the second phase of the formalin test (591.9&#61617; 26.1 s for control group vs. 444.3&#61617; 31.3 s for BTX-A-treated group ; p<0.01). Conclusion. Here we show that antinociceptive effect of peripherally applied BTX-A is limited within the innervation segment of particular sensory nerve. In line with that, antinociceptive effect of BTX-A could be achieved after direct injection into sensory ganglia. However, this oppose suggested peripheral mechanism of antinociceptive action of BTX-A. Supported by Croatian MZOS (108-1080003-0001 and 108-1080003-0020) and DAAD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080003-0001 - NEUROTRANSMITORI I NOVI MEHANIZMI DJELOVANJA LIJEKOVA I OTROVA (Lackovic, Zdravko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zdravko Lacković (autor)

Avatar Url Lidija Bach-Rojecky (autor)


Citiraj ovu publikaciju

Filipović, Boris; Bach-Rojecky, Lidija; Lacković Zdravko
Where to inject botulinum toxin in the treatment of pain? // 39th International Danaube Symposium ; Journal of Neural Transmission 114 ; 2007 / Riederer, Peter ; Gerlach, Manfred (ur.).
Wien, New York: Springer - Verlag, 2007. str. CXXVIII-CXXVIII (poster, nije recenziran, sažetak, znanstveni)
Filipović, B., Bach-Rojecky, L. & Lacković Zdravko (2007) Where to inject botulinum toxin in the treatment of pain?. U: Riederer, P. & Gerlach, M. (ur.)39th International Danaube Symposium ; Journal of Neural Transmission 114 ; 2007.
@article{article, year = {2007}, pages = {CXXVIII-CXXVIII}, keywords = {botulinum toxin, pain, nociception}, title = {Where to inject botulinum toxin in the treatment of pain?}, keyword = {botulinum toxin, pain, nociception}, publisher = {Springer - Verlag}, publisherplace = {Wuerzburg, Njema\v{c}ka} }
@article{article, year = {2007}, pages = {CXXVIII-CXXVIII}, keywords = {botulinum toxin, pain, nociception}, title = {Where to inject botulinum toxin in the treatment of pain?}, keyword = {botulinum toxin, pain, nociception}, publisher = {Springer - Verlag}, publisherplace = {Wuerzburg, Njema\v{c}ka} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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