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Pregled bibliografske jedinice broj: 347699

P63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca


Štifanić, Mauro; Mičić, Milena; Ramšak, Andreja, Blašković, Sanja; Ruso, Ana; Zahn, Rudolf K.; Batel, Renato
p63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca // Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 154 (2009), 3; 264-273 doi:10.1016/j.cbpb.2009.06.011 (međunarodna recenzija, članak, znanstveni)


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Naslov
P63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca

Autori
Štifanić, Mauro ; Mičić, Milena ; Ramšak, Andreja, Blašković, Sanja ; Ruso, Ana ; Zahn, Rudolf K. ; Batel, Renato

Izvornik
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (1096-4959) 154 (2009), 3; 264-273

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mollusca ; mytilus ; nomenclature ; p53 ; p63 ; p73 ; phylogeny ; sequence

Sažetak
Genes of the p53 family are known to be critical regulators of the cell cycle. They have already been established as possible biomarkers. Elaborate regulation mechanisms result in numerous cDNA and protein isoforms being expressed from each gene of the p53 family. Their similarity caused an often misleading nomenclature in non-vertebrate species. The aim of the present work is a clarification of the nomenclature of molluscan p53 family sequences, an essential prerequisite for reliable interpretation of gene expression and protein function studies. Here, we report five partial cDNA and one partial genomic p63 sequences, all originating from two Mytilus galloprovincialis individuals. DNA, deduced protein sequences, and the exon/intron architecture were analyzed and compared to p53, p63 and p73 sequences from other organisms. Along with our sequences, we analyzed all similar molluscan sequences found in the GenBank database. The analysis showed our cDNA sequences code for the TAp63γ isoform of the p63 protein, and identified all other molluscan p53 family sequences as p63 genes or their expression isoforms. Our results also indicate p63 as the ancestral gene of the p53 family as well as the only gene of the family present in non-chordate metazoan species.

Izvorni jezik
Engleski

Znanstvena područja
Geologija



POVEZANOST RADA


Projekti:
098-0982705-2724 - Učinak zagađenja na programirane biosinteze morskih beskralješnjaka (Batel, Renato, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Renato Batel (autor)

Avatar Url Ana Baričević (autor)

Avatar Url Mauro Štifanić (autor)

Avatar Url Milena Mičić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Štifanić, Mauro; Mičić, Milena; Ramšak, Andreja, Blašković, Sanja; Ruso, Ana; Zahn, Rudolf K.; Batel, Renato
p63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca // Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 154 (2009), 3; 264-273 doi:10.1016/j.cbpb.2009.06.011 (međunarodna recenzija, članak, znanstveni)
Štifanić, M., Mičić, M., Ramšak, Andreja, Blašković, Sanja, Ruso, A., Zahn, R. & Batel, R. (2009) p63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 154 (3), 264-273 doi:10.1016/j.cbpb.2009.06.011.
@article{article, author = {\v{S}tifani\'{c}, Mauro and Mi\v{c}i\'{c}, Milena and Ruso, Ana and Zahn, Rudolf K. and Batel, Renato}, year = {2009}, pages = {264-273}, DOI = {10.1016/j.cbpb.2009.06.011}, keywords = {mollusca, mytilus, nomenclature, p53, p63, p73, phylogeny, sequence}, journal = {Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology}, doi = {10.1016/j.cbpb.2009.06.011}, volume = {154}, number = {3}, issn = {1096-4959}, title = {p63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca}, keyword = {mollusca, mytilus, nomenclature, p53, p63, p73, phylogeny, sequence} }
@article{article, author = {\v{S}tifani\'{c}, Mauro and Mi\v{c}i\'{c}, Milena and Ruso, Ana and Zahn, Rudolf K. and Batel, Renato}, year = {2009}, pages = {264-273}, DOI = {10.1016/j.cbpb.2009.06.011}, keywords = {mollusca, mytilus, nomenclature, p53, p63, p73, phylogeny, sequence}, journal = {Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology}, doi = {10.1016/j.cbpb.2009.06.011}, volume = {154}, number = {3}, issn = {1096-4959}, title = {p63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca}, keyword = {mollusca, mytilus, nomenclature, p53, p63, p73, phylogeny, sequence} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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