engleski

Visual Analysis of Heart Reinervation after Transplantation

During heart transplantation complete denervation of allograft occurs. Partial reinnervation may develop after one year or later. It can be detected by different methods i.e., iodine-123-meta-iodobenziylguanidine (MIBG) scintigraphy, positron emission tomography (PET), heart rate variability (HRV), etc. We propose an alternative noninvasive method based on visual diagnostics (VD) and supported by a custom developed computer program (ComVis), which enables a global and a local view on the large amount of data to be analyzed in the same time. Measurements of patients with transplanted heart are rare and valuable, therefore they should be analyzed in all details. Different statistical characteristics and time series from ECG and respiration measurements from twelve patients and forty healthy controls have been inserted into the ComVis program. MIBG scintigraphy data from early and late imaging were included. Heart to mediastinum ratio (HMR) was used as a measure of the ventricular reinervation. HRV was analyzed to evaluate sinus node reinnervation. HRV was synchronized on well defined expiration moment and analyzed in time-domain. Finally, the whole set of data was considered in detail visually using ComVis. We will describe some new diagnostic results or rules that were deduction from visual analysis and may help in the future investigation of heart reinervation.

Visual analyses; herat reinervation; transplantation

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