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Pregled bibliografske jedinice broj: 347389

Angiotenzin converting enzyme activity and nitric oxide level in serum of patients with dehydration


Huskić, Jasminko; Čulo, Filip; Dautović, Sajma; Mulabegović, Nedžad
Angiotenzin converting enzyme activity and nitric oxide level in serum of patients with dehydration // Bosnian journal of basic medical sciences, 7 (2007), 1; 33-36 doi:10.17305/bjbms.2007.3086 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 347389 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Angiotenzin converting enzyme activity and nitric oxide level in serum of patients with dehydration

Autori
Huskić, Jasminko ; Čulo, Filip ; Dautović, Sajma ; Mulabegović, Nedžad

Izvornik
Bosnian journal of basic medical sciences (1512-8601) 7 (2007), 1; 33-36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Angiotenzin ; nitric oxide ; dehidration ; ACE
(Angiotenzin ; nitric oxide ; dehydration ; ACE)

Sažetak
Angiotensin converting enzyme (ACE) and nitric oxide (NO) have been suggested to be involved in the regulation of fluid homeostasis. In the present investigation, ACE activity and NO levels were determined in serum of 20 patients (10 men and 10 women) with dehydration caused by gastroenterocolitis and 20 healthy individuals (10 men and 10 women). Serum and tissue ACE activity was determined by spectrophotometric method using hippuryl-l-histidyl-l-leucine (Hip-His-Leu) as a substrate. NO synthesis was determined by measuring the products of NO, nitrite and nitrate. The concentration of nitrites was determined by classic colorimetric method using Griess reagent. Nitrate concentration was determined indirectly by their reduction with elementary zinc into nitrite. Results have shown that serum ACE activity in patients with dehydration (36, 46+/-2, 74 U/L) is statistically higher then in healthy individuals (28, 71+/-1, 77 U/L, p<0, 05). The average level of nitrites/nitrates in serum of patients with dehydration (30, 57+/-1, 05 microM ; mean +/- SEM) is also statistically higher then in healthy individuals (12, 44+/-0, 60 microM, p<0, 0001). There was no correlation between ACE activity and NO production. The results indicate that ACE and NO may participate in the regulation of the alteration in blood flow and in the regulation of the water balance in patients with dehydration.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Filip Čulo (autor)

Citiraj ovu publikaciju

Huskić, Jasminko; Čulo, Filip; Dautović, Sajma; Mulabegović, Nedžad
Angiotenzin converting enzyme activity and nitric oxide level in serum of patients with dehydration // Bosnian journal of basic medical sciences, 7 (2007), 1; 33-36 doi:10.17305/bjbms.2007.3086 (međunarodna recenzija, članak, znanstveni)
Huskić, J., Čulo, F., Dautović, S. & Mulabegović, N. (2007) Angiotenzin converting enzyme activity and nitric oxide level in serum of patients with dehydration. Bosnian journal of basic medical sciences, 7 (1), 33-36 doi:10.17305/bjbms.2007.3086.
@article{article, year = {2007}, pages = {33-36}, DOI = {10.17305/bjbms.2007.3086}, keywords = {Angiotenzin, nitric oxide, dehidration, ACE}, journal = {Bosnian journal of basic medical sciences}, doi = {10.17305/bjbms.2007.3086}, volume = {7}, number = {1}, issn = {1512-8601}, title = {Angiotenzin converting enzyme activity and nitric oxide level in serum of patients with dehydration}, keyword = {Angiotenzin, nitric oxide, dehidration, ACE} }
@article{article, year = {2007}, pages = {33-36}, DOI = {10.17305/bjbms.2007.3086}, keywords = {Angiotenzin, nitric oxide, dehydration, ACE}, journal = {Bosnian journal of basic medical sciences}, doi = {10.17305/bjbms.2007.3086}, volume = {7}, number = {1}, issn = {1512-8601}, title = {Angiotenzin converting enzyme activity and nitric oxide level in serum of patients with dehydration}, keyword = {Angiotenzin, nitric oxide, dehydration, ACE} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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