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Pregled bibliografske jedinice broj: 347241

Na+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine


Vitezić, Dinko; Mršić-Pelčić, Jasenka; Župan, Gordana; Vitezić, Miomira; Ljubičić, Đulijano; Simonić, Ante
Na+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine // Psychiatria Danubina, 20 (2008), 3; 269-276 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 347241 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Na+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine

Autori
Vitezić, Dinko ; Mršić-Pelčić, Jasenka ; Župan, Gordana ; Vitezić, Miomira ; Ljubičić, Đulijano ; Simonić, Ante

Izvornik
Psychiatria Danubina (0353-5053) 20 (2008), 3; 269-276

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Na+; K+-ATPase activity; hippocampus; cortex; kainic acid; lamotrigine

Sažetak
Kainic acid (KA) is used as an experimental agent which produces convulsions and neurotoxic lesions. Lamotrigine (LTG) is an antiepileptic drug, a glutamate release inhibitor, with action at the neuronal voltage-gated sodium channel. The aim of the present study was to investigate the Na+, K+-ATPase activity in the hippocampus and cortex of rats with KA-induced convulsions. Further, this study was also designed to investigate the influence of the LTG pre-treatment on the mentioned hippocampal and cortex changes. The study was carried out on Hannover-Wistar rats. Na+, K+-ATPase activity from hippocampal and temporal cortex tissue was determined two hours after a single subcutaneous KA (8 mg/kg) injection as well as on the third or the fifth experimental day. LTG (30 mg/kg i.p.) was used one hour before KA application and during the next two or four consecutive days. All animals of KA and KA+LTG groups were observed during the first 2 hours after KA application and their behavior was noted. Only animals with characteristically KA-induced behavioral changes observed were used in the study. KA typical behavioral changes were confirmed with electroencephalography. After KA application, Na+, K+-ATPase activity was significantly inhibited. Na+, K+-ATPase activity inhibition in the hippocampus of the LTG pretreated rats on the fifth experimental day was statistically less pronounced than in KA treated rats. The LTG pretreatment showed also a protective effect on the Na+, K+-ATPase activity in the rats’ brain cortex. KA systemic application induced Na+, K+-ATPase activity inhibition in the rat hippocampus and cortex and LTG pre-treatment showed a partially protective effect on the enzyme activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620529-0519 - Epilepsija i traumatska ozljeda mozga: mehanizmi oštećenja i farmakoterapija (Župan, Gordana, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka


Citiraj ovu publikaciju

Vitezić, Dinko; Mršić-Pelčić, Jasenka; Župan, Gordana; Vitezić, Miomira; Ljubičić, Đulijano; Simonić, Ante
Na+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine // Psychiatria Danubina, 20 (2008), 3; 269-276 (međunarodna recenzija, članak, znanstveni)
Vitezić, D., Mršić-Pelčić, J., Župan, G., Vitezić, M., Ljubičić, Đ. & Simonić, A. (2008) Na+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine. Psychiatria Danubina, 20 (3), 269-276.
@article{article, year = {2008}, pages = {269-276}, keywords = {Na+, K+-ATPase activity, hippocampus, cortex, kainic acid, lamotrigine}, journal = {Psychiatria Danubina}, volume = {20}, number = {3}, issn = {0353-5053}, title = {Na+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine}, keyword = {Na+, K+-ATPase activity, hippocampus, cortex, kainic acid, lamotrigine} }
@article{article, year = {2008}, pages = {269-276}, keywords = {Na+, K+-ATPase activity, hippocampus, cortex, kainic acid, lamotrigine}, journal = {Psychiatria Danubina}, volume = {20}, number = {3}, issn = {0353-5053}, title = {Na+, K+-ATPase Activity in the Brain of the Rats with Kainic Acid-Induced Seizures: Influence of Lamotrigine}, keyword = {Na+, K+-ATPase activity, hippocampus, cortex, kainic acid, lamotrigine} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • PsychINFO





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