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Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study


Benković, Vesna; Oršolić, Nada; Horvat Knežević, Anica; Ramić, Snježana; Đikić, Domagoj; Bašić, Ivan; Kopjar, Nevenka
Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study // Biological & pharmaceutical bulletin, 31 (2008), 1; 167-172 doi:10.1248/bpb.31.167 (međunarodna recenzija, članak, znanstveni)


Naslov
Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study

Autori
Benković, Vesna ; Oršolić, Nada ; Horvat Knežević, Anica ; Ramić, Snježana ; Đikić, Domagoj ; Bašić, Ivan ; Kopjar, Nevenka

Izvornik
Biological & pharmaceutical bulletin (0918-6158) 31 (2008), 1; 167-172

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Radioprotection; propolis; flavonoids; mice; alkaline comet assay

Sažetak
The radioprotective effects of water-soluble derivate of propolis (WSDP) collected in Croatia, and single flavonoids caffeic acid, chrysin and naringin in the whole-body irradiated CBA mice were investigated. Irradiation was performed using a γ -ray source (60Co), and absorbed doses were 4 and 9 Gy. The efficiency of test components was evaluated when given intraperitoneally (ip) at dose of 100 mg kg-1 for 3 consecutive days before and/or after irradiation. Moreover, possible genotoxic effects of all test components were assessed on non-irradiated animals. The higher efficiency of test components was observed when given preventively. The results suggest that propolis and related flavonoids given to mice before irradiation protect mice from lethal effects of whole-body irradiation and diminish primary DNA damage in their white blood cells as detected by the alkaline comet assay and micronucleus assay.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Nada Oršolić, )
119-0532265
119-0532265-1254 - Imunoadjuvantno i zaštitno djelovanje propolisa u životinja (Vesna Benković, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinika za tumore,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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