engleski

ALLELE FREQUENCIES OF 17 STR Y CHROMOSOME LOCI IN THE POPULATION OF REBUBLIC OF MACEDONIA

Allele frequencies of 17 STR loci (DYS19, DYS189I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385I/II, DYS438, DYS439, DYS437, DYS448, DYS456, DYS458, DYS635 and Y GATA H4) were determined in a sample of 100 unrelated individuals from the Republic of Macedonia. AmpFISTRYFiler Kit (Applied Biosystems) was used for PCR amplification. Allele frequencies of these loci have been compared with data obtained from geographically close European populations (Serbia, Kosovo, Bulgaria, Bosnia and Herzegovina and coastal part of Croatia). The significance level after Bonferroni&#8217; s correction was considered as p<0.01 except for DYS437 and DYS438 loci since for these comparisons only two populations was used because of lack of data. Exact tests of populations differentiation show statistically significant differences of allele frequencies of DSY385 locus between Macedonian and Serbia, Kosovo, Bosnia and Herzegovina populations (population from coastal part of Croatia was not considered in calculation). Almost the same result (excluding Kosovo population and including population from coastal part of Croatia) was noticed for DYS389- II locus. Macedonian and Kosovo populations show significant differences of allele frequencies for DYS392 loci as well as for DYS19. The significant difference result for latest mentioned locus was also recorded between Macedonian and population from coastal part of Croatia and for DYS390, DYS391 as well as DYS393 loci. Macedonian and Bosnian and Herzegovnian populations have significant difference in allele frequencies for DYS438 locus.

Y chromosome STR; Macedonian Population; Frequencies; Statistic; Comaparative

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