Propolis and related flavonoids as radioprotective agents (CROSBI ID 36354)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Oršolić, Nada ; Benković, Vesna ; Horvat-Knežević, Anica ; Bašić Ivan
engleski
Propolis and related flavonoids as radioprotective agents
Dietary factors play an important role in human health and in the development of certain chronic diseases including cancer. Polyphenolic compounds are widely distributed in the plant kingdom and display a variety of biological activities, including the free radical scavenging ability, tissue regeneration properties, immunostimulatory effects, chemoprevention and growth inhibition of tumors. It has been well established that biological effects of radiation result from energy deposition in irradiated cells in which reactive oxygen species (ROS), including superoxide anion (O2• ─ ), hydroxyl radical (OH• ) and hydrogen peroxide (H2O2) are produced. However, if overproduction of ROS occurs, oxidative damage can lead to radiation-induced cytotoxicity (chromosomal damage and mutations) or lethality. It is also widely believed that oxidative damage contributes significantly to the development of age-related chronic illness such as cancer and degenerative diseas. For these reasons, the search for new radioprotectors that are less toxic than the currently available compounds is crucially needed to develop better strategies for protecting exposed populations from radiation injury.
propolis, radioprotection, flavonoids, polyphenolic compounds,
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Podaci o prilogu
175-194.
objavljeno
Podaci o knjizi
Herbal Radiomodulators : Applications in Medicine, Homeland Defence and Space
Rajesh Arora
Wallingford: CABI Publishing
2008.
9781845933951