engleski

Determination of Psychophysiological and Hormonal Disturbances in the Groups of Depressive and Nondepressive Alcoholics

Acute and chronic alcohol intake and alcohol withdrawal induce disfunction of neuroendocrine and other regulatory system.. The aims of this study were to assess a possible HPA dysfunction in our population of alcoholics, using dexamethasone suppression test (DST). The serum and urinary cortisol were compared between the groups of 89 male patients (64.5 % depresive and 32 % nondepresive alcoholics) ( Hamilton test), before and after DST. In nondepressive patients, 50 % was nonsupressive in DST. In depressive patients 54 % was supressive in DST test( serum cortisol) . 24 hours urinary excretion in group of nondepresive patients was supressed only in 22 % of cases ; depressive patients showed 49.1 % nonsupresors. Basal serum cortisol secretion was significantly lower in group of nondepressive than depressive patients.Also, serum concentration at 16 h were significantly higher in group of the depressive nonsupressive patients. Basal urinary cortisol excretion was in normal range in all patients, but after dividing the patients in groups of supressors and nonsupressors, significantly higher (p<0,002) basal urinary cortisol concentrations were found in nonsupressive group.We concluded on the basis of DST test, as well basal cortisol measurement, the that the neuroendocrine disfunction of alcoholic patients could be present even the depression is still not pronounced.

Alcoholism; depression; psychophysiology; hormons

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