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Synthesis and Biological Activity of Mannose Conjugates with 1-Adamantamine and Ferrocene Amines


Ribić, Rosana; Kovačević, Monika; Petrović Peroković, Vesna; Gruić-Sovulj, Ita; Rapić, Vladimir; Tomić, Srđanka
Synthesis and Biological Activity of Mannose Conjugates with 1-Adamantamine and Ferrocene Amines // Croatica chemica acta, 83 (2010), 4; 421-431 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and Biological Activity of Mannose Conjugates with 1-Adamantamine and Ferrocene Amines

Autori
Ribić, Rosana ; Kovačević, Monika ; Petrović Peroković, Vesna ; Gruić-Sovulj, Ita ; Rapić, Vladimir ; Tomić, Srđanka

Izvornik
Croatica chemica acta (0011-1643) 83 (2010), 4; 421-431

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
O-Mannopyranosides; 1-adamantamine; ferrocene amines; hemagglutination

Sažetak
Pure α- and β-anomers of O-mannosyl conjugates with 1-adamantamine and ferrocene amines were prepared. The sugar moiety in these glycoconjugates is connected to the amine by a chiral linker (methyl (R)-3-hydroxy-2-methyl propanoate and/or methyl (S)-3-hydroxy-2-methyl propanoate). The α-D-mannopyranosides with adamantane and ferrocene aglycon parts were tested using the hemagglutination assay (inhibition of the agglutination of guinea pig erythrocytes by type 1 fimbriated E. coli HB101 (pPKl4)). All glycoconjugates showed inhibitory potencies in the mM range.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
058-1191344-3122 - Metalocenski biokonjugati, heterocikli i makromolekule (Veronika Kovač, )
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Prehrambeno-biotehnološki fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus