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The mechanisms of UV radiation in the development of malignant melanoma


Šitum, Mirna; Buljan, Marija; Ožanić-Bulić, Suzana; Šimić, Dubravka
The mechanisms of UV radiation in the development of malignant melanoma // Collegium Antropologicum, 31 (2007), Supplement 1; 13-16 (podatak o recenziji nije dostupan, članak, ostalo)


Naslov
The mechanisms of UV radiation in the development of malignant melanoma

Autori
Šitum, Mirna ; Buljan, Marija ; Ožanić-Bulić, Suzana ; Šimić, Dubravka

Izvornik
Collegium Antropologicum (0350-6134) 31 (2007), Supplement 1; 13-16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
UV radiation; melanoma; photoimmunology; oncogene

Sažetak
The sunlight was one of the first agents recognized to be carcinogenic for humans. There is convincing evidence from epidemiologic studies that exposure to solar radiation is the major cause of cutaneous melanoma in light-pigmented populations and plays a role in the increasing incidence of this malignancy. The molecular mechanisms by which UV radiation exerts its varied effects are not completely understood, however, it is considered that UVA and UVB are equally critical players in melanoma formation. Whereas UVA can indirectly damage DNA through the formation of reactive oxygen radicals, UVB can directly damage DNA causing the apoptosis of keratinocytes by forming the sunburn cells. Besides action through mutations in critical regulatory genes, UV radiation may promote cancer through indirect mechanisms, e.g. immunosuppression and dysregulation of growth factors. The carcinogenic process probably involves multiple sequential steps, some, but not all of which involve alterations in DNA structure.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
134-1342428-2420 - Psihološki status bolesnika s različitim dermatozama i zloćudnim bolestima kože (Mirna Šitum, )

Ustanove
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE