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Pregled bibliografske jedinice broj: 345847

High performance mass spectrometry for compositional and structural analysis of human brain gangliosides


Vukelić, Željka; Kalanj-Bognar, Svjetlana; Zamfir, Alina D.
High performance mass spectrometry for compositional and structural analysis of human brain gangliosides // 1st Advanced Research Workshop on Applications of Mass Spectrometry in Life Safety, The NATO Science for Peace and Security Programme
Arad (Herkulane), Rumunjska, 2007. (predavanje, nije recenziran, neobjavljeni rad, znanstveni)


Naslov
High performance mass spectrometry for compositional and structural analysis of human brain gangliosides

Autori
Vukelić, Željka ; Kalanj-Bognar, Svjetlana ; Zamfir, Alina D.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Izvornik
1st Advanced Research Workshop on Applications of Mass Spectrometry in Life Safety, The NATO Science for Peace and Security Programme / - Arad (Herkulane), Rumunjska, 2007

Skup
1st Advanced Research Workshop on Applications of Mass Spectrometry in Life Safety, The NATO Science for Peace and Security Programme

Mjesto i datum
Herkulane, Rumunjska, 23-27.09.2007

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Detection and structural identification of gangliosides; advanced mass spectrometry approaches; biomarkers

Sažetak
Gangliosides, sialylated glycosphingolipids, are the most abundant in cells, particularly plasma-membranes, of the mammalian central nervous system. They participate in many vital cellular events such as cell-to-cell communication and signaling. In this contribution our results related to the following topics were presented. Human brain ganglioside composition shows regional, developmental, and ageing specificity, while characteristic changes of the normal pattern have been observed in various neuropathological conditions. Our studies of human brain gangliosides by modern ultra-sensitive mass spectrometric approaches complemented with conventional chromatographic and immunochemical methods documented that specific ganglioside patterns contain much larger number of individual species than previously reported. Advantages of these methodologies for accurate and reliable composition/structure and structure-function analysis of brain gangliosides in health and neurological diseases (brain tumors, Alzheimer’ s disease) were elaborated. Also, challenging aspects of ganglioside investigation as potential diagnostic biomarkers and/or therapeutic targets/agents were summarized.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1877 - Uloga membranskih lipida u moždanom razvitku, starenju i neurodegeneraciji (Svjetlana Kalanj-Bognar, )
108-1081870-2415 - Strukturno-funkcionalna glikolipidomika moždanog razvitka i maligne alteracije (Željka Vukelić, )

Ustanove
Medicinski fakultet, Zagreb