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Pregled bibliografske jedinice broj: 345099

Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics


Vagić, Davor; Ferenčić, Željko; Drviš, Petar; Geber, Goran; Džidić, Senka; Baudoin Tomislav; Kalogjera, Livije
Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics // European Archives of Oto-Rhino-Laryngology, 265 (2008), 10; 1205-1209 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 345099 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics

Autori
Vagić, Davor ; Ferenčić, Željko ; Drviš, Petar ; Geber, Goran ; Džidić, Senka ; Baudoin Tomislav ; Kalogjera, Livije

Izvornik
European Archives of Oto-Rhino-Laryngology (0937-4477) 265 (2008), 10; 1205-1209

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sinus lavage; histomorphometry; immunohistochemistry; ECP; MPO; Tryptase; Eosinophil; Th-2; Bacteria; Superantigen

Sažetak
The aim of the study was to show the difference in the pattern of inflammation, and Th1/Th2 polarization between asthmatic and non-asthmatic patients with CRS, specifically eosinophil activation, local IgE levels in the sinus fluid and tissue, and the severity of inflammation were measured. The maxillary sinus lavages, mucosal biopsies and bacteriological swabs were taken in 17 asthmatic and 36 non-asthmatic adult patients with CRS. The concentrations of IgE, eosinophil cationic protein (ECP), myeloperoxidase (MPO), and tryptase were analyzed and IgE+ cells, eosinophils, lymphocytes and plasma cells were counted. The granulocyte activation markers and IgE in sinus lavages, and the inflammatory and IgE+ cells counts were significantly higher in the asthmatics with the greatest difference in ECP and IgE concentrations. The tryptase concentrations did not differ, but only in the asthmatics they correlated significantly with the IgE concentrations and IgE+ cells count. Asthmatic patients present a distinct subgroup among the patients with chronic rhinosinusitis (CRS). The levels of the cellular markers and IgE in the sinus fluid differ from those of non-asthmatic patients with CRS. The activation of granulocytes (especially eosinophils), local IgE concentrations and the inflammatory cells infiltration are significantly higher in the asthmatics.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
065-0650235-0145 - Istraživanje međuodnosa alergije i infekcije u rinosinuitisu i nosnoj polipozi (Kalogjera, Livije, MZOS ) ( POIROT)
108-0650235-0177 - Istraživanje kroničnog rinosinuitisa i njegova komorbiditeta (Baudoin, Tomislav, MZOS ) ( POIROT)

Ustanove:
Stomatološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Vagić, Davor; Ferenčić, Željko; Drviš, Petar; Geber, Goran; Džidić, Senka; Baudoin Tomislav; Kalogjera, Livije
Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics // European Archives of Oto-Rhino-Laryngology, 265 (2008), 10; 1205-1209 (međunarodna recenzija, članak, znanstveni)
Vagić, D., Ferenčić, Ž., Drviš, P., Geber, G., Džidić, S., Baudoin Tomislav & Kalogjera, L. (2008) Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics. European Archives of Oto-Rhino-Laryngology, 265 (10), 1205-1209.
@article{article, year = {2008}, pages = {1205-1209}, keywords = {sinus lavage, histomorphometry, immunohistochemistry, ECP, MPO, Tryptase, Eosinophil, Th-2, Bacteria, Superantigen}, journal = {European Archives of Oto-Rhino-Laryngology}, volume = {265}, number = {10}, issn = {0937-4477}, title = {Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics}, keyword = {sinus lavage, histomorphometry, immunohistochemistry, ECP, MPO, Tryptase, Eosinophil, Th-2, Bacteria, Superantigen} }
@article{article, year = {2008}, pages = {1205-1209}, keywords = {sinus lavage, histomorphometry, immunohistochemistry, ECP, MPO, Tryptase, Eosinophil, Th-2, Bacteria, Superantigen}, journal = {European Archives of Oto-Rhino-Laryngology}, volume = {265}, number = {10}, issn = {0937-4477}, title = {Local IgE and inflammation in chronic rhinosinusitis of asthmatics and non-asthmatics}, keyword = {sinus lavage, histomorphometry, immunohistochemistry, ECP, MPO, Tryptase, Eosinophil, Th-2, Bacteria, Superantigen} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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