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Pregled bibliografske jedinice broj: 344218

Genetic and epigenetic regulation of Hh-Gli signaling pathway in ovarian tumors


Čretnik, Maja; Musani, Vesna; Orešković, Slavko; Levanat, Sonja
Genetic and epigenetic regulation of Hh-Gli signaling pathway in ovarian tumors // Sažeci Četvrtog hrvatskog kongresa iz humane genetike s međunarodnim sudjelovanjem / Paediatria Croatica 51 (Suppl.) / Barišić, Ingeborg (ur.).
Zagreb: Klinika za dječje bolesti Zagreb, 2007. str. 162-162 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 344218 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic and epigenetic regulation of Hh-Gli signaling pathway in ovarian tumors

Autori
Čretnik, Maja ; Musani, Vesna ; Orešković, Slavko ; Levanat, Sonja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Sažeci Četvrtog hrvatskog kongresa iz humane genetike s međunarodnim sudjelovanjem / Paediatria Croatica 51 (Suppl.) / Barišić, Ingeborg - Zagreb : Klinika za dječje bolesti Zagreb, 2007, 162-162

Skup
Četvrti hrvatski kongres iz humane genetike

Mjesto i datum
Malinska, Hrvatska, 18-20.10.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
genetics ; epigenetics ; Hh-Gli signaling pathway ; PTCH promoter

Sažetak
Hedgehog-Gli is a signaling pathway involved in embryonic development and its malfunctioning is often associated with tumorigenesis. Binding of the ligand protein Hedgehog to its receptor Patched (Ptch) causes Ptch to relieve its repression of the co-receptor Smoothened (Smo). Smo then activates a signaling cascade which activates transcription factor Gli which translocates to the nucleus and induces transcription of target genes. These are genes involved in cell cycle progression and proliferation, and also Ptch itself, which acts as a negative regulator of the pathway. Mutations in Ptch, a tumor suppressor gene, are the cause of a genetic disorder named Gorlin syndrome. Gorlin syndrome is characterized with multiple malformations (pits of palm and soles, spina bifida, cleft lip and palate, hydrocephalus) and tumors (basocellular carcinomas, dermoids of heart and ovary, medulloblastoma). Malfunctioning of this pathway is also involved in various sporadic tumors not associated with the syndrome, namely lung, colon, skin, ovarian and breast). We investigated function of this pathway in sporadic cases of ovarian dermoids and fibromas. We examined expression of various pathway genes and found it was deregulated, but mutation analysis showed no mutations and little LOH events. That led us to examination of methylation status of PTCH promoter. We found increased methylation in both ovarian dermoids and fibromas in relation to normal ovarian tissue. We concluded that aberrant methylation is one of the steps in tumorigenesis of these types of tumors.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
MZOS-098-0982464-2461 - Prijenos signala u tumorima: Hh-Gli put, interakcije i potencijalne terapije (Levanat, Sonja, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Vesna Musani (autor)

Avatar Url Sonja Levanat (autor)

Avatar Url Slavko Orešković (autor)

Avatar Url Maja Sabol (autor)


Citiraj ovu publikaciju

Čretnik, Maja; Musani, Vesna; Orešković, Slavko; Levanat, Sonja
Genetic and epigenetic regulation of Hh-Gli signaling pathway in ovarian tumors // Sažeci Četvrtog hrvatskog kongresa iz humane genetike s međunarodnim sudjelovanjem / Paediatria Croatica 51 (Suppl.) / Barišić, Ingeborg (ur.).
Zagreb: Klinika za dječje bolesti Zagreb, 2007. str. 162-162 (poster, nije recenziran, sažetak, znanstveni)
Čretnik, M., Musani, V., Orešković, S. & Levanat, S. (2007) Genetic and epigenetic regulation of Hh-Gli signaling pathway in ovarian tumors. U: Barišić, I. (ur.)Sažeci Četvrtog hrvatskog kongresa iz humane genetike s međunarodnim sudjelovanjem / Paediatria Croatica 51 (Suppl.).
@article{article, editor = {Bari\v{s}i\'{c}, I.}, year = {2007}, pages = {162-162}, keywords = {genetics, epigenetics, Hh-Gli signaling pathway, PTCH promoter}, title = {Genetic and epigenetic regulation of Hh-Gli signaling pathway in ovarian tumors}, keyword = {genetics, epigenetics, Hh-Gli signaling pathway, PTCH promoter}, publisher = {Klinika za dje\v{c}je bolesti Zagreb}, publisherplace = {Malinska, Hrvatska} }
@article{article, editor = {Bari\v{s}i\'{c}, I.}, year = {2007}, pages = {162-162}, keywords = {genetics, epigenetics, Hh-Gli signaling pathway, PTCH promoter}, title = {Genetic and epigenetic regulation of Hh-Gli signaling pathway in ovarian tumors}, keyword = {genetics, epigenetics, Hh-Gli signaling pathway, PTCH promoter}, publisher = {Klinika za dje\v{c}je bolesti Zagreb}, publisherplace = {Malinska, Hrvatska} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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