HLA-G polymorphisms: ethnic differences and implications for potential molecule function. (CROSBI ID 85133)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
van der Ven, K. ; Škrablin, Snježana ; Ober, C. ; Krebs, D.
engleski
HLA-G polymorphisms: ethnic differences and implications for potential molecule function.
PROBLEM: Human leukocyte antigen (HLA)-G is uniquely expressed on extravillous cytotrophoblasts of the placenta and is postulated to be a mediator of maternal immune tolerance. Although it was originally considered to be nonpolymorphic, variations of the HLA-G DNA sequence have been reported, and a limited number of HLA-G alleles been defined. METHOD OF STUDY: The HLA-G wild-type sequence was compared with HLA-A2 with regard to the conservation of functionally essential parts of classical HLA-I molecules. HLA-G polymorphisms were analyzed under the aspect of ethnic differences, site, and consequences for postulated molecule functions. RESULTS: HLA-G exhibits a high degree of conservation relative to HLA-A2 in functionally relevant sites of HLA-class I molecules. However, polymorphic sites in HLA-G and classical HLA loci are not congruent. CONCLUSION: The type and localization of HLA-G polymorphisms suggest that different parts of HLA-G molecule underlie different selective constraints.
HLA-G polymorphisms ; ethnic differences
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Podaci o izdanju
40 (3)
1998.
145-157
objavljeno
1600-0897
10.1111/j.1600-0897.1998.tb00406.x