engleski

Correlation between serum butyrylcholinesterase activity abd serum lipid concentrations in rats treated with different antagonists of the adrenergic system

The purpose of this study was to evaluate the effects of different adrenergic antagonists on butyrylcholinesterase activity (BuChE) and to investigate the correlation between BuChE activity and serum lipids. Six groups of male Fischer rats were treated orally with adrenergic antagonists (mixed in commercial diet) during 6 weeks: oxprenolol, atenolol, doxazosin, oxprenolol and doxazosin, atenolol and doxazosin, and guanethidine. BuChE activity in serum was determined with kinetic color test using butyrylthiocholine as a substrate. Concentrations of serum lipids (total cholesterol, triglycerides and HDL cholesterol) were determined by enzymatic colorimetric tests. Data were analyzed by Kruskal-Wallis test and Sperman's correlation coefficinet. The results revealed that oxprenolol and doxazosin (given alone or in combination with atenolol or oxprenolol) increased (>30%) BuChE activity. BuChE activity correlated with different serum lipids, and correlation depended on the type of adrenergic blockade.

butyrylcholinesterase; high-density lipoprotein; low-density lipoprotein; triglycerides; antagonists of the adrenergic system

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