Cellular functions of phosphoinositide 3-kinase C2beta (CROSBI ID 536595)
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Podaci o odgovornosti
Banfić, Hrvoje
engleski
Cellular functions of phosphoinositide 3-kinase C2beta
The large family of phosphoinositide 3-kinase (PI3K) enzymes can be divided into three distinct classes (I, II and III) based on the sequence similarity and lipid products they generate in vitro. In mammalian cells there are three class II PI3K isoforms, and PI3K-C2beta act as downstream targets of growth factor, chemokine and integrin receptors. The proline-rich motifs within the N-terminal region of PI3K-C2beta mediate its association with activated receptor, and the enzyme regulates cell migration, suggesting its potential role in tumour metasthasis. In Drosophila melanogaster, ectopic expression of the enzyme in the larval marginal disks affected the development of the wings, and the number of external sense organs, suggesting a role of the enzyme in the signalling pathways affecting pattering. Furthermore, the enzyme is localized in the nucleus and is activated during G2/M phase of the cell cycle via calpain-mediated proteolysis Enzyme contains nuclear localization sequence within C2 domain, which is crucial for its nuclear localization and translocation.
PI3KC2b
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Podaci o prilogu
24-24.
2007.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Periodicum biologorum
Banfić, H ; Boban, M ; Francetić, I ; Klarica, M ; Muck-Šeler, D ; Pivac, N ; Sabolić, I ; Tvrdeić, A ; Župan, G.
Zagreb: Hrvatsko prirodoslovno društvo
0031-5362
Podaci o skupu
5th CROATIAN CONGRESS OF PHARMACOLOGICAL AND 2nd CONGRESS OF CROATIAN PHYSIOLOGICAL SOCIETY
pozvano predavanje
19.09.2007-22.09.2007
Osijek, Hrvatska