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Pregled bibliografske jedinice broj: 342257

Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer’ s disease and diabetes mellitus.


Tahirovic, Ismet; Sofic, Emin; Sapcanin, Aida; Bah-Rojecky, Lidija; Salkovic-Petrisic, Melita; Lackovic, Zdravko; Hoyer, Siegfried; Riederer, Peter
Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer’ s disease and diabetes mellitus. // J Neural Transm / Riederer, Peter (ur.).
Wien: Springer, 2007. str. DP-03-10-DP-03-10 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 342257 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer’ s disease and diabetes mellitus.

Autori
Tahirovic, Ismet ; Sofic, Emin ; Sapcanin, Aida ; Bah-Rojecky, Lidija ; Salkovic-Petrisic, Melita ; Lackovic, Zdravko ; Hoyer, Siegfried ; Riederer, Peter

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
J Neural Transm / Riederer, Peter - Wien : Springer, 2007, DP-03-10-DP-03-10

Skup
39th International Danube Symposium and the 1st International Congress on ADHD

Mjesto i datum
Wuerzburg, Njemačka, 2-5.06.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Antioxidant Capacity; Streptozotocin; Brain; Alzheimer's Disease; Diabetes Mellitus

Sažetak
Objective. Adult, 2-4 months old Wistar rats were used throughout the study. The initial samples consisted of 35 rats treated with ST, TG and controls (C) were used. In all experiments including those with diabetes induction all animals were kept on standardized food pellets and water ad libitum. Peripheral application of high doses of streptozotocin (STZ) produce experimental diabetes mellitus. The objective of this study was to evaluate the effects of STZ and thioglucose (TG) on the antioxidant capacities of rat brain hippocampus (HPC), cerebellum (CB) and brain stem (BS). Methods. Antioxidant capacity in the supernatants was measured using oxygen radical absorbance capacity (ORAC) assay. Results. The results showed that ORAC against hydroxyl radical in HPC of treated rats for 3 months with TG, and TG+STZ decreased significantly in comparison with C. Furthermore, ORAC against peroxyl radical in HPC of treated rats with TG decreased significantly iin comparison with C. We found, also that hydroxyl radical in CB and BS of treated rats for 12 weeks with TG, and TG+STZ decreased significantly in comparison with C. Conclusion. The upregulation of antioxidant systems in the various brain regions (HPC, CB and BS) of treated rats with TG and TG+STZ were found.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080003-0020 - Mozak, eksperimentalni i cerebralni dijabetes i kognitivni i drugi poremećaji (Šalković-Petrišić, Melita, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Tahirovic, Ismet; Sofic, Emin; Sapcanin, Aida; Bah-Rojecky, Lidija; Salkovic-Petrisic, Melita; Lackovic, Zdravko; Hoyer, Siegfried; Riederer, Peter
Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer’ s disease and diabetes mellitus. // J Neural Transm / Riederer, Peter (ur.).
Wien: Springer, 2007. str. DP-03-10-DP-03-10 (poster, međunarodna recenzija, sažetak, znanstveni)
Tahirovic, I., Sofic, E., Sapcanin, A., Bah-Rojecky, L., Salkovic-Petrisic, M., Lackovic, Z., Hoyer, S. & Riederer, P. (2007) Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer’ s disease and diabetes mellitus.. U: Riederer, P. (ur.)J Neural Transm.
@article{article, editor = {Riederer, P.}, year = {2007}, pages = {DP-03-10-DP-03-10}, keywords = {Antioxidant Capacity, Streptozotocin, Brain, Alzheimer's Disease, Diabetes Mellitus}, title = {Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer and \#8217; s disease and diabetes mellitus.}, keyword = {Antioxidant Capacity, Streptozotocin, Brain, Alzheimer's Disease, Diabetes Mellitus}, publisher = {Springer}, publisherplace = {Wuerzburg, Njema\v{c}ka} }
@article{article, editor = {Riederer, P.}, year = {2007}, pages = {DP-03-10-DP-03-10}, keywords = {Antioxidant Capacity, Streptozotocin, Brain, Alzheimer's Disease, Diabetes Mellitus}, title = {Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer and \#8217; s disease and diabetes mellitus.}, keyword = {Antioxidant Capacity, Streptozotocin, Brain, Alzheimer's Disease, Diabetes Mellitus}, publisher = {Springer}, publisherplace = {Wuerzburg, Njema\v{c}ka} }




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