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The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma


Jaganjac, Morana; Poljak-Blaži, Marija; Žarković, Kamelija; Joerg Schaur, Rudolf; Žarković, Neven
The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma // Cancer Letters, 260 (2008), 1-2; 180-186 doi:10.1016/j.canlet.2007.10.039 (međunarodna recenzija, članak, znanstveni)


Naslov
The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma

Autori
Jaganjac, Morana ; Poljak-Blaži, Marija ; Žarković, Kamelija ; Joerg Schaur, Rudolf ; Žarković, Neven

Izvornik
Cancer Letters (0304-3835) 260 (2008), 1-2; 180-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Oxidative burst; granulocytes; Walker 256 carcinoma; anti-cancer effects; spontaneous tumour regression; sephadex; tumor-cell lysis; polymorphonuclear leukocytes; nonoxidative mechanisms; human-neutrophils; oxidative burst; cancer-patients; cytotoxicity; therapy; phagocytosis; mice

Sažetak
We described before that oxidative burst of granulocytes is cytotoxic for melanoma B16F10 and for Walker 256 carcinoma (W256). Therefore, we assumed that granulocytes could also be important mechanism of the host defence against tumour. In current study we report massive granulocyte infiltration at the site of W256 transplanted in the hind limb of Sprague– Dawley associated with spontaneous tumour regression observed for 22/25 rats (87%). Peripheral blood granulocytes of these animals were highly cytotoxic for W256 cells cultured in vitro. After the tumour disappearance the inflammatory oxidative burst of the granulocytes ended. Distraction of granulocytes from the tumour by s.c. Sephadex injection decreased the incidence of the W256 regression to only 7/25 animals (30%). These results suggest that innate immunity based on immune competent granulocytes may be the cause of well known phenomenon of spontaneous regression of W256 carcinoma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )
198-0000000-3104 - Uloga neutrofila i oksidacijskog stresa u operacijama kolorektalnog karcinoma (Igor Stipančić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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