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Pregled bibliografske jedinice broj: 339146

Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus


Tahirović, Ismet; Sofić, Emin; Šapčanin, Aida; Gavrankapetanović, Ismet; Bach-Rojecky, Lidija; Šalković-Petrišić, Melita; Lacković, Zdravko; Hoyer, Siegfried; Riederer, Peter
Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus // Journal of Neural Transmission. Supplementum, 2007 (2007), Suppl. 72; 235-240 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 339146 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus

Autori
Tahirović, Ismet ; Sofić, Emin ; Šapčanin, Aida ; Gavrankapetanović, Ismet ; Bach-Rojecky, Lidija ; Šalković-Petrišić, Melita ; Lacković, Zdravko ; Hoyer, Siegfried ; Riederer, Peter

Izvornik
Journal of Neural Transmission. Supplementum (0303-6995) 2007 (2007), Suppl. 72; 235-240

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Rat; Streptozotocin; Diabetes Mellitus; Antioxidant Capacity; Oxidative Stress

Sažetak
It is believed that oxidative stress plays a central role ini the pathogenesis of metabolic diseases like diabetes mellitus (DM) and its complications (like peripheral neuropathy) as well as in neurodegenerative disorders like sporadic Alzheimer's disease (sAD). Representative experimental models of these diseases are streptozotocin (STZ)-induced diabetic rats and STZ-intracerebroventricularly (STZ-icv) treated rats, in whichantioxidant caoacity against peroxyl (ORAC-ROO*) and hydroxyl (ORAC-OH*) free radical was measured in three different brain regions (hippocampus, cerebellum, and brain stem) by means of oxygen radical absorbance capacity (ORAC) assay. in the brain of both STZ-induced diabetic and STZ-icv treated rats decreased antioxidant capacity has been found demonstrating regionally specific distribution. In the diabetic rats these abnormalities were not associated with the development of peripheral diabetic neuropathy. Also, these abnormalities were not prevented by the icv pretreatment of glucose transport inhibitor 5-thio-D-glucose in the STZ-icv treated rats, suggesting different mechanism for STZ-induced central effects from those at the periphery. Similarities in the oxidative stress alterations in the brain of STZ-icv rats and humans with sAD could be useful in the search for new drugs in the treatment of sAD that have antioxidant activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Rad je sličan prvotno objavljenom radu Tahirovic et al., Neurochemical Res 2007 ; 32:1709-1717, a objavljen je uz dozvolu ko-autora i glavnog urednika J Neural Transm.



POVEZANOST RADA


Projekti:
108-1080003-0001 - NEUROTRANSMITORI I NOVI MEHANIZMI DJELOVANJA LIJEKOVA I OTROVA (Lackovic, Zdravko, MZOS ) ( POIROT)
108-1080003-0020 - Mozak, eksperimentalni i cerebralni dijabetes i kognitivni i drugi poremećaji (Šalković-Petrišić, Melita, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Tahirović, Ismet; Sofić, Emin; Šapčanin, Aida; Gavrankapetanović, Ismet; Bach-Rojecky, Lidija; Šalković-Petrišić, Melita; Lacković, Zdravko; Hoyer, Siegfried; Riederer, Peter
Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus // Journal of Neural Transmission. Supplementum, 2007 (2007), Suppl. 72; 235-240 (međunarodna recenzija, članak, znanstveni)
Tahirović, I., Sofić, E., Šapčanin, A., Gavrankapetanović, I., Bach-Rojecky, L., Šalković-Petrišić, M., Lacković, Z., Hoyer, S. & Riederer, P. (2007) Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus. Journal of Neural Transmission. Supplementum, 2007 (Suppl. 72), 235-240.
@article{article, year = {2007}, pages = {235-240}, keywords = {Rat, Streptozotocin, Diabetes Mellitus, Antioxidant Capacity, Oxidative Stress}, journal = {Journal of Neural Transmission. Supplementum}, volume = {2007}, number = {Suppl. 72}, issn = {0303-6995}, title = {Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus}, keyword = {Rat, Streptozotocin, Diabetes Mellitus, Antioxidant Capacity, Oxidative Stress} }
@article{article, year = {2007}, pages = {235-240}, keywords = {Rat, Streptozotocin, Diabetes Mellitus, Antioxidant Capacity, Oxidative Stress}, journal = {Journal of Neural Transmission. Supplementum}, volume = {2007}, number = {Suppl. 72}, issn = {0303-6995}, title = {Brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus}, keyword = {Rat, Streptozotocin, Diabetes Mellitus, Antioxidant Capacity, Oxidative Stress} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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