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Prognostic significance of ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma


Projić, Petar; Šamija, Ivana; Bezić, Joško; Tomić, Snježana; Anđelinović, Šimun
Prognostic significance of ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma // Geburtshilfe und Frauenheilkunde, 67 (2007), 5; 475-479 doi:10.1055/s-2007-965245 (međunarodna recenzija, članak, znanstveni)


Naslov
Prognostic significance of ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma

Autori
Projić, Petar ; Šamija, Ivana ; Bezić, Joško ; Tomić, Snježana ; Anđelinović, Šimun

Izvornik
Geburtshilfe und Frauenheilkunde (0016-5751) 67 (2007), 5; 475-479

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA index; flow cytometry; ovarian cancer; ploidy

Sažetak
Paraffin-embedded tissue from sixty-one ovarian epithelial cancers were analyzed by histology and flow cytometry.The results of DNA analysis were correlated with clinicopathologic data.For univariate survival analysis we used the Kaplan-Meier model and log-rank test to asses the differences between the groups.For multivariate analysis, Cox proportional hazard regression model was used to examine several parameters simultaneously. Aneuploidy was significantly associated with advanced clinical stage, menopausal status, high grade, serous histological type and vascular invasion. Univariate analysis showed that aneuploidy and DNA index were associated with shorter overall survival. Multivariate analysis showed only vascular invasion as an independent prognostic factor. Although abnormal DNA content was associated with traditional clinicopathological characteristics for aggresive tumors and shorter overall survival, aneuploidy and high DNA index had no independent prognostic value in our study.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-0000000-0484 - Dvostruki model ovarijalne kancerogeneze - molekularna i morfološka studija (Snježana Tomić, )

Ustanove
Medicinski fakultet, Split

Citiraj ovu publikaciju

Projić, Petar; Šamija, Ivana; Bezić, Joško; Tomić, Snježana; Anđelinović, Šimun
Prognostic significance of ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma // Geburtshilfe und Frauenheilkunde, 67 (2007), 5; 475-479 doi:10.1055/s-2007-965245 (međunarodna recenzija, članak, znanstveni)
Projić, P., Šamija, I., Bezić, J., Tomić, S. & Anđelinović, Š. (2007) Prognostic significance of ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma. Geburtshilfe und Frauenheilkunde, 67 (5), 475-479 doi:10.1055/s-2007-965245.
@article{article, year = {2007}, pages = {475-479}, DOI = {10.1055/s-2007-965245}, keywords = {DNA index, flow cytometry, ovarian cancer, ploidy}, journal = {Geburtshilfe und Frauenheilkunde}, doi = {10.1055/s-2007-965245}, volume = {67}, number = {5}, issn = {0016-5751}, title = {Prognostic significance of ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma}, keyword = {DNA index, flow cytometry, ovarian cancer, ploidy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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