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Prognostic significance of ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma

Paraffin-embedded tissue from sixty-one ovarian epithelial cancers were analyzed by histology and flow cytometry.The results of DNA analysis were correlated with clinicopathologic data.For univariate survival analysis we used the Kaplan-Meier model and log-rank test to asses the differences between the groups.For multivariate analysis, Cox proportional hazard regression model was used to examine several parameters simultaneously. Aneuploidy was significantly associated with advanced clinical stage, menopausal status, high grade, serous histological type and vascular invasion. Univariate analysis showed that aneuploidy and DNA index were associated with shorter overall survival. Multivariate analysis showed only vascular invasion as an independent prognostic factor. Although abnormal DNA content was associated with traditional clinicopathological characteristics for aggresive tumors and shorter overall survival, aneuploidy and high DNA index had no independent prognostic value in our study.

DNA index; flow cytometry; ovarian cancer; ploidy

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