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Effect of age on fibrinogen and C-reactive protein in patients with acute coronary syndromes (CROSBI ID 535484)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Vrsalović, Mislav ; Nikolić-Heitzler, Vjeran ; Pavlov, Marin ; Vrkić, Nada ; Raić, Biserka ; Getaldić, Biserka ; Petrač, Dubravko Effect of age on fibrinogen and C-reactive protein in patients with acute coronary syndromes // European journal of cardiovascular prevention & rehabilitation / Pantaleo Giannuzzi, David A Wood (ur.). 2007. str. S23-S23

Podaci o odgovornosti

Vrsalović, Mislav ; Nikolić-Heitzler, Vjeran ; Pavlov, Marin ; Vrkić, Nada ; Raić, Biserka ; Getaldić, Biserka ; Petrač, Dubravko

engleski

Effect of age on fibrinogen and C-reactive protein in patients with acute coronary syndromes

Objectives Increasing age is an important risk factor for cardiovascular disease, but the mechanisms of risk are still not well understood. Rising levels of inflammatory markers might be responsible for the excess in thrombotic events that develops with aging. Patient! ; anil Methods I'atients (pts) with acute coronary syndromes (ACS), 62% males: 1553 with ST-elevation myocardial infarction, 397 with non-ST-elevation myocardial infarction, 912 with unstable angina, were included in the study. Fibrinogen, determined using the Clauss assay, and C-reactive protein (CRP), determined by immunot'irbidimetric method, were obtained at the time of admission. Patients were divided into four groups: A < 55 years of age (592 pts), 15 55-65 years (706 pts), C 65-75 years (930 pts), ' I) > 75 years (634 pts). Results Significant difference (p < 0.01) was obtained between groups for both fibrinogen and CRP which persisted after adjusting for sex, cardiovascular risk factors (diabetes, smoking, hypertension, hyperlipi-demia) and type of ACS. Post hoc analysis revealed statistically significant difference between groups A and C, A and D, B and C, B and D for both fibrioogen and CRP (the mean fibrinogen levels were: 4.19: 4.39 ; 4.76 ; 4.78g/L and mean CRP levels were: 17.0 ; 23.6 ; 33.7 ; 38.9mg/L for groups A-D respectively). Both fibrinogen and CRP correlated significantly with advancing age (r = 0.18 for both fibrinogen and CRP, p< 0.001).' Conclusion These results may partly explain the elevated incidence and more common complications of cardiovascular disease in the elderly.

fibrinogen; CRP; acute coronary syndrome

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Podaci o prilogu

S23-S23.

2007.

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objavljeno

Podaci o matičnoj publikaciji

European journal of cardiovascular prevention & rehabilitation

Pantaleo Giannuzzi, David A Wood

London : Delhi: Lippincott Williams and Wilkins

1741-8267

Podaci o skupu

EUROPREVENT 2007

poster

19.04.2007-21.04.2007

Madrid, Španjolska

Povezanost rada

Farmacija

Indeksiranost