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izvor podataka: crosbi

Integrated gene networks in breast cancer development (CROSBI ID 139308)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Ratkaj, Ivana ; Štajduhar, Emil ; Vučinić, Srđan ; Spaventi, Šime ; Pavelić, Krešimir ; Bošnjak, Hrvojka ; Kraljević Pavelić, Sandra Integrated gene networks in breast cancer development // Functional & integrative genomics, 10 (2010), 1; 11-19. doi: 10.1007/s10142-010-0159-2

Podaci o odgovornosti

Ratkaj, Ivana ; Štajduhar, Emil ; Vučinić, Srđan ; Spaventi, Šime ; Pavelić, Krešimir ; Bošnjak, Hrvojka ; Kraljević Pavelić, Sandra

engleski

Integrated gene networks in breast cancer development

Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the "omics". Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.

breast cancer ; metastasis ; functional genomics

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Podaci o izdanju

10 (1)

2010.

11-19

objavljeno

1438-793X

1438-7948

10.1007/s10142-010-0159-2

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost