Transcriptional expression and functional activity of mu-opioid receptors (MOR) on myelo-monocytic HL-60 cell line (CROSBI ID 535406)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Gabrilovac, Jelka ; Breljak, Davorka ; Čupić, Barbara
engleski
Transcriptional expression and functional activity of mu-opioid receptors (MOR) on myelo-monocytic HL-60 cell line
Opioid receptors, highly expressed on cells of central nervous system, were also found on cells of hematopoietic origin, but at much lower density. In this study we have examined transcriptional expression of mu-opioid receptors (MOR) on HL-60 cells of myelo-monocytic origin, at their basal state. Functionality of the MOR on these cells was examined by following Ca++ mobilization triggered by selective agonist of alkaloid (morphine) and peptide (endomorphin-2) structure. The data obtained have shown that cells of myelo-monocytic HL-60 line, at their basal state, express MOR both at the level of mRNA and at the level of a functionally active protein capable of transmitting intracellular signals via Ca++ upon ligation with selective agonists of alkaloid or peptide structure.
mu-opioid receptors ; transcriptional expression ; functional activity ; morphine ; endomorphin-2
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
287-292.
2007.
objavljeno
Podaci o matičnoj publikaciji
8th International Congress of Neuroimmunology Free Papers
Takashi, Tabira ; Takashi, Yamamura ; Junichi, Kira
Bolonja: Monduzzi Editore S.p.A. - Medimond Inc., International Proceedings Division
978-88-7587-324-0
7891-352X
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predavanje
29.02.1904-29.02.2096