Napredna pretraga

Pregled bibliografske jedinice broj: 335674

Expression of cell cycle and apoptosis regulatory proteins and telomerase in melanocitic lesions


Batinac, Tanja; Hadžisejdić, Ita; Brumini, Gordana; Ružić, Alen; Vojniković, Božidar; Zamolo, Gordana
Expression of cell cycle and apoptosis regulatory proteins and telomerase in melanocitic lesions // Collegium antropologicum, 31 (2007), Suppl 1; 17-22 (međunarodna recenzija, članak, znanstveni)


Naslov
Expression of cell cycle and apoptosis regulatory proteins and telomerase in melanocitic lesions

Autori
Batinac, Tanja ; Hadžisejdić, Ita ; Brumini, Gordana ; Ružić, Alen ; Vojniković, Božidar ; Zamolo, Gordana

Izvornik
Collegium antropologicum (0350-6134) 31 (2007), Suppl 1; 17-22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bcl-2; Melanoma; Nevi; Telomerase

Sažetak
To gain insight into the role and association of cell cycle and apoptosis regulatory proteins and telomerase activity in the course of progression of melanocitic lesions we have examined immunohistochemicaly, expression and the distribution of p53, bcl-2, Ki-67 and telomerase in 25 samples of common and dysplastic nevi, and 45 samples of primary invasive melanomas. Protein p53 expression was significantly increased in dysplastic as compared with common nevi and melanomas (p < 0.001). Bcl-2 protein expression was significantly increased in melanomas as compared with common aquired and dysplastic nevi (p = 0.001). Nevi and melanomas exhibited clear-cut differences in terms of Ki-67 expression. Telomerase expression was significantly increased in melanomas as compared with common acquired (p = 0.014) and dysplastic nevi (p < 0.001). Enhanced telomerase activity in association with increased bcl-2 expression in the course of melanoma progression could contribute to development and progression of melanoma.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Marija Kaštelan, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Anthropological Literature
  • International Bibliography of the Social Sciences (IBSS)
  • MEDLINE
  • Sociological Abstracts