engleski

Is renal erythropoietin secretion consequence of local hypoxia coupled with local suppression of angiogenesis?

It has recently been reported that angiogenesis is suppressed in the normal kidney tissue by the local production of ineffective VEGF165b (Schumacher VA et al. J Am Soc Nephrol 2007 ; 18:719-29). Due to restricted angiogenesis in normal kidney tissue, it seems that the chronically hypoxic kidney medulla might have been the reason that made kidneys the main source of erythropoietin secretion, as a rescue mode that increases local oxygen delivery. Cells in any hypoxic part of the kidney interstitial space, surrounded by capillaries with oxygen depleted blood that returns from medulla, are probably hypoxic enough to secrete erythropoietin.

VEGF; angiogenesis; erythropoietin; kidney medulla; urine concentration; hypoxia

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