engleski

Breast cancer morphometry

Fine needle aspiration cytology (FNAC) has very important role in diagnosis of breast cancer. In this study economic and simple method was investigated as possible supplement for improve diagnostic accuracy of cytology. Aim: The aim of the study was to compare morphometric parameters between different types of breast cancers. Patients and Methods: 36 patients were selected: 6 patients with invasive ductal carcinoma grade I (I DCI) ; 9 patients with invasive ductal carcinoma grade II (IDC II) ; 13 patients with invasive ductal carcinoma grade III /IDC III) ; 5 patients with invasive lobular carcinoma (ILC) and 3 patients with tubulo-Iobular carcinoma (TLC). The following parameters were investigated: area, outline, max. radius, min. radius, convex area, breadth, length, nuclear/cytoplasmatic ratio, form factor and elongation. Statistic 7.1, x2-test were used. Results: Morphometric analysis shown statistically significant differences (p<0, 05) between following investigated groups: IDC I/IDC II ; IDC I/IDC III ; IDC II/III ; IDC II/ILC ; IDC III/TLC ; IDC III/ILC ; - cell: area, convex area, nucleus: area, convex area, outline. IDC I/TLC ; IDC II/TLC ; IDC IIl/ILC - cell: area, convex area ; nucleus: area, convex area. IDC I/ILC - cell: area, convex area, outline ; nucleus: area, convex area. Conclusions: Morphometric parameters considered individually were highly associated with type and grade of breast tumour.

Breast cancer; FNAC; image analysis; morphometry

nije evidentirano