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Pregled bibliografske jedinice broj: 334488

I-131 beta S-factors for various geometry models in dosimetry of thyroid remnants


Grošev, Darko; Lončarić, Srećko; Huić, Dražen; Dodig, Damir
I-131 beta S-factors for various geometry models in dosimetry of thyroid remnants // Sixth international congress of the croatian society of nuclear medicine, May 9-12, 2008, Opatija
Zagreb, 2008. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 334488 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
I-131 beta S-factors for various geometry models in dosimetry of thyroid remnants

Autori
Grošev, Darko ; Lončarić, Srećko ; Huić, Dražen ; Dodig, Damir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Sixth international congress of the croatian society of nuclear medicine, May 9-12, 2008, Opatija / - Zagreb, 2008

Skup
Sixth international congress of the croatian society of nuclear medicine, May 9-12, 2008, Opatija

Mjesto i datum
Opatija, Hrvatska, 9.-12.5.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
internal dosimetry; radioiodine ablation; absorbed fraction; Monte Carlo calculation

Sažetak
The effectiveness of radioiodine ablation therapy, after total thyriodectomy in patients with well differentiated thyroid cancer, could be optimised using quantitative dosimetry. For this purpose the accurate knowledge of the geometric features of the remnant tissue is important, since the S-factor (mean absorbed dose per unit cumulated activity) depends on remnant mass and beta self-absorbed fraction. Using Monte Carlo (MC) simulation, beta absorbed fraction, &#934; &#946; , was calculated for I-131 within following geometrical models: sphere, cylinder, and ellipsoid. The complete beta spectrum of I-131 was used, as well as uniform beta activity throughout the object. According to the MIRD model, beta S-factors (mGy/MBq*s) were calculated for chordal lengths < 1cm and/or masses < 1g, where the escape of beta energy becomes relevant. For all geometrical models, &#934; &#946; is always smaller for the complete beta spectrum, then for just using mean 131I beta energy (0.182 MeV). This leads, for example, to 37 % overestimation of the S-factors for sphere of radius 1 mm, which drops to 11 % for sphere with r=3 mm. For thin elongated objects (cylinder with h=10 mm, r=1 mm, or spheroid with a=b=1 mm, c=5 mm) S-factors are Scyl= 7.60E-01 and Sspheroid= 1.11E+00, which are greater than the S-factor for sphere of the same maximal chordal length (diameter, d=10 mm), Ssphere= 5.47E-02 mGy/(MBq*s) . The values of S-factors presented could be helpful in assessing the potential dosimetric errors related to the inaccurate remnant mass determination due to the resolution loss of the imaging equipment.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0362214-0127 - Korekcija gušenje zračenja u emisijskoj tomografiji srca (Dodig, Damir, MZOS ) ( POIROT)
214-0362214-2055 - Kvantifikacija i parametrizacija akumulacije FDG-a pomoću PET-a (Lončarić, Srećko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Damir Dodig (autor)

Avatar Url Dražen Huić (autor)

Avatar Url Srećko Lončarić (autor)

Avatar Url Darko Grošev (autor)


Citiraj ovu publikaciju:

Grošev, Darko; Lončarić, Srećko; Huić, Dražen; Dodig, Damir
I-131 beta S-factors for various geometry models in dosimetry of thyroid remnants // Sixth international congress of the croatian society of nuclear medicine, May 9-12, 2008, Opatija
Zagreb, 2008. (poster, međunarodna recenzija, sažetak, znanstveni)
Grošev, D., Lončarić, S., Huić, D. & Dodig, D. (2008) I-131 beta S-factors for various geometry models in dosimetry of thyroid remnants. U: Sixth international congress of the croatian society of nuclear medicine, May 9-12, 2008, Opatija.
@article{article, year = {2008}, keywords = {internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation}, title = {I-131 beta S-factors for various geometry models in dosimetry of thyroid remnants}, keyword = {internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation}, publisherplace = {Opatija, Hrvatska} }
@article{article, year = {2008}, keywords = {internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation}, title = {I-131 beta S-factors for various geometry models in dosimetry of thyroid remnants}, keyword = {internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation}, publisherplace = {Opatija, Hrvatska} }




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