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Pregled bibliografske jedinice broj: 334372

Geometric models in dosimetry of thyroid remnant mass


Grošev, Darko; Lončarić, Srećko; Huić, Dražen; Dodig, Damir
Geometric models in dosimetry of thyroid remnant mass // Nuklearmedizin, 47 (2008), 3; 120-126 (međunarodna recenzija, članak, znanstveni)


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Naslov
Geometric models in dosimetry of thyroid remnant mass

Autori
Grošev, Darko ; Lončarić, Srećko ; Huić, Dražen ; Dodig, Damir

Izvornik
Nuklearmedizin (0029-5566) 47 (2008), 3; 120-126

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Internal dosimetry; radioiodine ablation; absorbed fraction; Monte Carlo calculation

Sažetak
Aim: Absorbed dose to thyroid remnant tissue after 131I ablation becomes mass/size-dependent. This is a direct consequence of the small remnant size and radiation escape starts to be relevant. The self-absorbed fraction becomes mass/size-dependent. We have used Monte Carlo simulations to investigate the influence of the thyroid remnant shape upon the absorbed fraction calculation. Methods: Thyroid residue was modeled using spherical, cylindrical and elliptical shapes. Uniform beta activity distribution and unit density medium (water) within a remnant was assumed. For each of the geometrical models beta self-absorbed fraction (&#966; &#946; ) was calculated using Monte Carlo codes, while the mean absorbed dose per unit cumulated activity (S&#946; ) was calculated using MIRD formalism. Results: For spherical objects &#966; mono for mean beta energy (E = 0.182 MeV) of 131I is always greater than &#966; &#946; calculated for the complete beta spectrum. For spheres having diameters 2&#8211; 6 mm and assumption &#966; &#946; =1, S&#946; is overestimated by 11&#8211; 37%. For cylinder and prolate spheroid of the same length and thickness, S&#946; for cylinder is 30% smaller because of the greater mass. Similarly, elliptical cylinder and general ellipsoid of the same length and the same perpendicular dimensions (width and breadth), have similar &#966; &#946; , while S&#946; for elliptical cylinder is correspondingly smaller. Conclusion: For accurate dosimetry of thyroid remnants having masses <1 g and chordal lengths <1 cm it is necessary to calculate &#966; &#946; for the full beta spectrum, or S&#946; will be overestimated. The shape of the remnant may also be important since elongated non-spherical objects may also have &#966; &#946; < 1.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0362214-0127 - Korekcija gušenje zračenja u emisijskoj tomografiji srca (Dodig, Damir, MZOS ) ( POIROT)
214-0362214-2055 - Kvantifikacija i parametrizacija akumulacije FDG-a pomoću PET-a (Lončarić, Srećko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Damir Dodig (autor)

Avatar Url Dražen Huić (autor)

Avatar Url Srećko Lončarić (autor)

Avatar Url Darko Grošev (autor)


Citiraj ovu publikaciju

Grošev, Darko; Lončarić, Srećko; Huić, Dražen; Dodig, Damir
Geometric models in dosimetry of thyroid remnant mass // Nuklearmedizin, 47 (2008), 3; 120-126 (međunarodna recenzija, članak, znanstveni)
Grošev, D., Lončarić, S., Huić, D. & Dodig, D. (2008) Geometric models in dosimetry of thyroid remnant mass. Nuklearmedizin, 47 (3), 120-126.
@article{article, year = {2008}, pages = {120-126}, keywords = {Internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation}, journal = {Nuklearmedizin}, volume = {47}, number = {3}, issn = {0029-5566}, title = {Geometric models in dosimetry of thyroid remnant mass}, keyword = {Internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation} }
@article{article, year = {2008}, pages = {120-126}, keywords = {Internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation}, journal = {Nuklearmedizin}, volume = {47}, number = {3}, issn = {0029-5566}, title = {Geometric models in dosimetry of thyroid remnant mass}, keyword = {Internal dosimetry, radioiodine ablation, absorbed fraction, Monte Carlo calculation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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