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Oximes as antidotes in therapy against tabun poisoning


Čalić, Maja; Kovarik, Zrinka; Berend, Suzana; Lucić Vrdoljak, Ana; Radić, Božica
Oximes as antidotes in therapy against tabun poisoning // 11th Medical Chemical Defence Conference, Sulfur Mustard: "Novel Targets for Intervention", Munchen, Njemačka, Programme
Munchen, Njemačka, 2008. str. 34-34 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Oximes as antidotes in therapy against tabun poisoning

Autori
Čalić, Maja ; Kovarik, Zrinka ; Berend, Suzana ; Lucić Vrdoljak, Ana ; Radić, Božica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th Medical Chemical Defence Conference, Sulfur Mustard: "Novel Targets for Intervention", Munchen, Njemačka, Programme / - , 2008, 34-34

Skup
11th Medical Chemical Defence Conference, Sulfur Mustard: Novel Targets for Intervention

Mjesto i datum
Munchen, Njemačka, 23-24.04.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Oximes; antidotes; theraphy; pretreatment; tabun; K048; K074

Sažetak
To the present time, only four pyridinium oximes, TMB-4, 2-PAM, HI-6 and obidoxime, have found clinical application in the therapy of organophosphorus compounds poisoning. Treatment with these oximes still has disadvantages, in example ; they all have limited reactivation potency in nerve agent tabun poisoning. We tested different oximes varying in structure to find more effective oximes to reactivate tabun inhibited human erythrocyte AChE. Two of our tested pyridinium oximes, K048 and K074, were the most promising for AChE reactivation with the overall reactivation rate constants (kr) of 673 and 2375 M-1min-1, respectively. Oximes are also reversible inhibitors of AChE and in that way exhibit protection against phosphorylation by tabun. Therefore, we tested K048 and K074 in vivo on tabun poisoned mice not only as antidotes in combination with atropine but also as pretreatment drug. The highest TF and TD (22.5 and 10.0, respectively) were obtained when we applied K048 in a dose of 25 % of its LD50 in pretreatment and treatment. This is a considerable increase in protection of mice compared to K048 treatment alone (TF = 8.0, TD = 5.0). Whatever are the shortcomings of using the reversible inhibitors as protectors, we have shown that already promising treatment in tabun poisoning by oximes and atropine could be significantly improved if oximes are also used in pretreatment. This finding may provide a platform for further modifications and development of more potent protectors and reactivators in organophosphorus compounds poisoning.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
022-0222148-2139 - Terapijski učinak novosintetiziranih spojeva pri otrovanju organofosfatima (Ana Lucić Vrdoljak, )
022-0222148-2889 - Interakcije organofosfata, karbamata i određenih liganada s esterazama (Zrinka Kovarik, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb