Napredna pretraga

Pregled bibliografske jedinice broj: 333732

Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets


Domitrović, Robert; Tota, Marin; Milin, Čedomila
Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets // Nutrition Research, 28 (2008), 4; 263-269 doi:10.1016/j.nutres.2008.01.007 (međunarodna recenzija, članak, znanstveni)


Naslov
Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets

Autori
Domitrović, Robert ; Tota, Marin ; Milin, Čedomila

Izvornik
Nutrition Research (0271-5317) 28 (2008), 4; 263-269

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Olive oil; corn oil; diet; iron; retinol; alpha-tocopherol; TBARS; mice

Sažetak
The influence of dietary fats on cellular alpha-tocopherol and retinol uptake in iron overload is poorly understood. The aim of this study was to investigate the effect of a high-iron diet on the retinol and alpha-tocopherol levels in mice fed olive oil– and corn oil– enriched diets. Mice were fed for 3 weeks a standard mouse chow (the control group) and diets enriched with 5% by weight of corn oil or olive oil. Diets of the mice fed corn oil and olive oil were additionally supplemented with 1% by weight carbonyl iron. Both dietary oils and iron increased the liver iron uptake. High-iron feeding induced oxidative stress in mice liver, measured as a thiobarbituric acid-reactive substance level. Both fats and iron induced changes in the liver fatty acid composition. Liver retinol and alpha-tocopherol stores increased with iron supplementation in the olive oil– enriched diet, with a simultaneous decrease in serum. The results suggest that the influx of alpha-tocopherol and retinol from serum to the liver is induced by high dietary iron. This redistribution appears to be stronger for retinol than for alpha-tocopherol and is also higher in mice fed olive oil than in mice fed corn oil, suggesting that the composition of dietary lipids is important in the treatment of high-iron tissue conditions. In conclusion, the results of this study suggest that the increase of hepatic alpha-tocopherol and retinol levels in the olive oil– based diet is a dietary-dependent responsive mechanism that probably is not primarily related to an increased risk of oxidative damage induced by high-iron intake.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-3554 - Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre (Robert Domitrović, )
062-0621341-0061 - Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva. (Čedomila Milin, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • BIOMED
  • Elsevier BIOBASE
  • SCISEARCH
  • Scopus


Citati