Glycotoxines, Carbonyl Stress and Relevance to Diabetes and its Complications (CROSBI ID 138860)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Turk, Zdenka
engleski
Glycotoxines, Carbonyl Stress and Relevance to Diabetes and its Complications
A large body of evidence has implicated reactive carbonyl compounds as glycotoxic mediators of carbonyl stress. This review is focused on the physiopathologic effects of alpha-dicarbonyls in diabetes and related complications, summarizing the state-of-the-art on the endogenously produced carbonyls: methylglyoxal, glyoxal and 3-deoxyglucosone, formed as glycolytic intermediates during metabolic conversion of glucose, via Maillard reaction by degradation of glycated proteins, and during lipid peroxidation process. Their participation in the advanced glycation process and detrimental effects on vascular tissue are discussed. In addition, the analytical methods for their detection and measurement are described.
diabetes; carbonyl stress; methylglyoxal; glyoxal and 3-deoxyglucosone
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