engleski

Ubiquitin signals in the NF-kappaB pathway

The NF-kappaB (nuclear factor kappaB) transcription factors control cell survival, proliferation and innate and adaptive immune response. Post-translational modifications of key components of the NF-kappaB pathway provide the molecular basis for signal transmission from the cell membrane to the nucleus. Here, we describe the involvement of different types of ubiquitin modification in the regulation of the NF-kappaB signalling pathway.

de-ubiquitinating enzyme; inhibitory kB kinase (IKK); nuclear factor kB (NF-kB); transcription factor; tumour necrosis factor receptor (TNFR); ubiquitination.

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