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Pregled bibliografske jedinice broj: 333311

Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology


Sertić, Jadranka; Slaviček, Jasna; Božina, Nada; Malenica, Branko; Kes, Petar; Reiner, Željko
Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology // Clinical Chemistry and Laboratory Medicine, 45 (2007), 10; 1347-1352 doi:10.1515/CCLM.2007.321 (međunarodna recenzija, članak, znanstveni)


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Naslov
Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology

Autori
Sertić, Jadranka ; Slaviček, Jasna ; Božina, Nada ; Malenica, Branko ; Kes, Petar ; Reiner, Željko

Izvornik
Clinical Chemistry and Laboratory Medicine (1434-6621) 45 (2007), 10; 1347-1352

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytokines; growth factors; atherosclerotic patients; hemodialysis; biochip array technology

Sažetak
Background: The lifespan of patients with chronic renal failure (CRF) is reduced, and coronary artery disease is the leading cause of morbidity and mortality in these patients. The progression of atherosclerosis is accelerated and angiogenesis is impaired in CRF. Risk factors that could contribute to further understanding of vascular pathology include markers of inflammation and growth factors. The purpose of this study was to determine the levels of cytokines (IL-2, IL4, IL-6, IL-8, IL-10, IL-1 alpha, IL-1 beta), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interferon-gamma (IFN gamma), tumor necrosis factor-alpha (TNF(alpha) and monocyte chemotactic protein-1 (MCP-1) in patients on chronic hemodialysis (HD ; n=75), and to compare values with those of control subjects (n = 113). Methods: Evidence (R) biochip array analyzer was used for quantification of plasma concentrations in samples. Results: Significant differences were found between the control subjects and HD patients. IL-2 (p < 0.001), IL-4 (p < 0.001) and EGF (p < 0.001) levels were higher in controls than in HD patients, while IL-6 (p < 0.001, IL-8 (p=0.081), IL-10 (p=0.008), TNF alpha (p < 0.001), IL-1 beta (p < 0.001) and MCP-1 (p < 0.001) levels were higher in HD patients. We also found IL-2 (p=0.015) and IL-1 alpha(x (p=0.035) levels to be significantly higher in males than females, while IL-4 (p=0.025) and IL-1 beta (p=0.049) levels were significantly higher in females.Among HD patients, IL-2 levels were higher in patients under the age of 50 years (p < 0.048). It was also higher in female than in male patients (p < 0.035) and in patients on HD for more than 10 years (p < 0.009). IL-6 levels were higher in patients over the age of 50 years (p < 0.047). Patients with previous glomerulonephritis had the highest level of IL-6 compared to patients with previous pyelonephritis and diabetes mellitus (p < 0.063). IL-6 levels were higher in patients with concomitant hepatitis C virus (HCV) infection (p < 0.036) and in patients with developed atherosclerosis (p < 0.003). IL-8 levels were higher in patients over the age of 50 years (p < 0.003) and in the group with previous glomerulonephritis (p < 0.031). IL-10 levels were higher in the group with developed atherosclerosis (p < 0.045). EGF was the highest in the group of patients with previous diabetes mellitus compared to pyelonephritis and glomerulonephritis groups (p < 0.073). TNF alpha levels were higher in the patient population on HD for more than 10 years (p < 0.032) and in the concomitant HCV group (p < 0.073). IL-1 beta levels were higher in the HCV group (p < 0.088). Conclusions: Plasma concentrations of some cytokines and growth factors could serve as useful diagnostic and prognostic parameters for patients with CRF on HD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080134-0121 - Percepcija i prevencija čimbenika rizika za aterosklerozu u Hrvatskoj (Reiner, Željko, MZOS ) ( POIROT)
108-1080134-0136 - Funkcijska genomika i proteomika rizičnih čimbenika ateroskleroze (Sertić, Jadranka, MZOS ) ( POIROT)
214-1081874-0168 - Regulacijski limfociti u sistemskim autoimunim bolestima (Malenica, Branko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Jasna Slaviček (autor)

Avatar Url Željko Reiner (autor)

Avatar Url Nada Božina (autor)

Avatar Url Jadranka Sertić (autor)

Avatar Url Branko Malenica (autor)

Avatar Url Petar Kes (autor)

Poveznice na cjeloviti tekst rada:

doi www.reference-global.com

Citiraj ovu publikaciju:

Sertić, Jadranka; Slaviček, Jasna; Božina, Nada; Malenica, Branko; Kes, Petar; Reiner, Željko
Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology // Clinical Chemistry and Laboratory Medicine, 45 (2007), 10; 1347-1352 doi:10.1515/CCLM.2007.321 (međunarodna recenzija, članak, znanstveni)
Sertić, J., Slaviček, J., Božina, N., Malenica, B., Kes, P. & Reiner, Ž. (2007) Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology. Clinical Chemistry and Laboratory Medicine, 45 (10), 1347-1352 doi:10.1515/CCLM.2007.321.
@article{article, author = {Serti\'{c}, Jadranka and Slavi\v{c}ek, Jasna and Bo\v{z}ina, Nada and Malenica, Branko and Kes, Petar and Reiner, \v{Z}eljko}, year = {2007}, pages = {1347-1352}, DOI = {10.1515/CCLM.2007.321}, keywords = {cytokines, growth factors, atherosclerotic patients, hemodialysis, biochip array technology}, journal = {Clinical Chemistry and Laboratory Medicine}, doi = {10.1515/CCLM.2007.321}, volume = {45}, number = {10}, issn = {1434-6621}, title = {Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology}, keyword = {cytokines, growth factors, atherosclerotic patients, hemodialysis, biochip array technology} }
@article{article, author = {Serti\'{c}, Jadranka and Slavi\v{c}ek, Jasna and Bo\v{z}ina, Nada and Malenica, Branko and Kes, Petar and Reiner, \v{Z}eljko}, year = {2007}, pages = {1347-1352}, DOI = {10.1515/CCLM.2007.321}, keywords = {cytokines, growth factors, atherosclerotic patients, hemodialysis, biochip array technology}, journal = {Clinical Chemistry and Laboratory Medicine}, doi = {10.1515/CCLM.2007.321}, volume = {45}, number = {10}, issn = {1434-6621}, title = {Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technology}, keyword = {cytokines, growth factors, atherosclerotic patients, hemodialysis, biochip array technology} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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