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Aberrant Glycosylation of IgG Heavy Chain in Multiple Myeloma (CROSBI ID 138711)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Aurer, Igor ; Lauc, Gordan ; Dumić, Jerka ; Rendić, Dubravko ; Matišić, Danica ; Miloš, Marija ; Heffer-Lauc, Marija ; Flogel, Mirna ; Labar, Boris Aberrant Glycosylation of IgG Heavy Chain in Multiple Myeloma // Collegium antropologicum, 31 (2007), 1; 247-251

Podaci o odgovornosti

Aurer, Igor ; Lauc, Gordan ; Dumić, Jerka ; Rendić, Dubravko ; Matišić, Danica ; Miloš, Marija ; Heffer-Lauc, Marija ; Flogel, Mirna ; Labar, Boris

engleski

Aberrant Glycosylation of IgG Heavy Chain in Multiple Myeloma

Although the majority of eukaryotic proteins are glycosylated, there is a dearth of knowledge regarding protein sugar moieties and their changes in disease. Most multiple myeloma cases are characterized by production of monoclonal immunoglobulins (Ig). We studied galactosylation and sialylation of IgG heavy chains in 16 patients with IgG myeloma using lectin blotting and densitometry. In comparison to age and sex matched controls, galactosylation was reduced in multiple myeloma (median 317 vs. 362, range 153-410 vs. 309-447 relative units, p=0.015, Student’ s t-test). Sialylation was stage dependent ; samples from patients with stage IIA had lowest amounts of sialic acid, IIIA intermediate and IIIB highest (142.6 vs. 185.9 vs. 248.5 relative units, correlation coefficient r=0.55). Both galactosylation and sialylation levels were independent of age, sex, treatment type, response to treatment, disease duration and IgG and b2 microglobulin concentration. These data indicate that multiple myeloma is characterized by aberrant immunoglobulin glycosylation.

multiple myeloma ; immunoglobulins ; glycosylation ; sialylation ; galactosylation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

31 (1)

2007.

247-251

objavljeno

0350-6134

Povezanost rada

Biologija, Kliničke medicinske znanosti

Poveznice
Indeksiranost