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Pregled bibliografske jedinice broj: 332294

Activation of ERK and JNK MAP kinases in optic nerves of rats exposed to global cerebral ischemia


Mršić-Pelčić, Jasenka; Pelčić, Goran, Vitezić, Dinko; Ljubičić, Đulijano; Župan, Gordana; Simonić, Ante
Activation of ERK and JNK MAP kinases in optic nerves of rats exposed to global cerebral ischemia // Psychiatria Danubina, 20 (2008), 4; 456-460 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 332294 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Activation of ERK and JNK MAP kinases in optic nerves of rats exposed to global cerebral ischemia

Autori
Mršić-Pelčić, Jasenka ; Pelčić, Goran, Vitezić, Dinko ; Ljubičić, Đulijano ; Župan, Gordana ; Simonić, Ante

Izvornik
Psychiatria Danubina (0353-5053) 20 (2008), 4; 456-460

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ERK; JNK; optic nerves; global cerbral ischemia; rat

Sažetak
To determine the influence of global cerebral ischemia on the activation of extracellular-regulated kinases (ERK) and c-Jun N-terminal kinases (JNK) in optic nerves of rats exposed to different reperfusion periods. Transient global cerebral ischemia (20-min duration) was induced by the four-vessel occlusion method. After different reperfusion periods (5 and 10 min ; 1 ; 6 and 12 h after ischemia), optic nerves were extracted and ERK and JNK activation signals were determined by Western immunoblot analyses. The activation signals of ERK and JNK were detected within first 10 min of reperfusion, but striking activation for both enzymes was found 1 h after ischemia. After transient decrease, the activation of ERK returned to peak level after 12 h of reperfusion in the second wave of kinase activation. In that period, slight increase of JNK activation was registered. Our results demonstrated for the first time that ERK and JNK were activated in rat optic nerves during early and later periods of reperfusion, suggesting their potential active role in the response of cerebral white matter tissue to ischemic injury.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620529-0518 - Molekularni mehanizmi ishemijskog oštećenja mozga i neuroprotekcija (Mršić-Pelčić, Jasenka, MZOS ) ( POIROT)
062-0620529-0519 - Epilepsija i traumatska ozljeda mozga: mehanizmi oštećenja i farmakoterapija (Župan, Gordana, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka


Citiraj ovu publikaciju

Mršić-Pelčić, Jasenka; Pelčić, Goran, Vitezić, Dinko; Ljubičić, Đulijano; Župan, Gordana; Simonić, Ante
Activation of ERK and JNK MAP kinases in optic nerves of rats exposed to global cerebral ischemia // Psychiatria Danubina, 20 (2008), 4; 456-460 (međunarodna recenzija, članak, znanstveni)
Mršić-Pelčić, J., Pelčić, Goran, Vitezić, Dinko, Ljubičić, Đ., Župan, G. & Simonić, A. (2008) Activation of ERK and JNK MAP kinases in optic nerves of rats exposed to global cerebral ischemia. Psychiatria Danubina, 20 (4), 456-460.
@article{article, year = {2008}, pages = {456-460}, keywords = {ERK, JNK, optic nerves, global cerbral ischemia, rat}, journal = {Psychiatria Danubina}, volume = {20}, number = {4}, issn = {0353-5053}, title = {Activation of ERK and JNK MAP kinases in optic nerves of rats exposed to global cerebral ischemia}, keyword = {ERK, JNK, optic nerves, global cerbral ischemia, rat} }
@article{article, year = {2008}, pages = {456-460}, keywords = {ERK, JNK, optic nerves, global cerbral ischemia, rat}, journal = {Psychiatria Danubina}, volume = {20}, number = {4}, issn = {0353-5053}, title = {Activation of ERK and JNK MAP kinases in optic nerves of rats exposed to global cerebral ischemia}, keyword = {ERK, JNK, optic nerves, global cerbral ischemia, rat} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • PsychINFO





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