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Pregled bibliografske jedinice broj: 331310

Reduction of cisplatin-induced nephrotoxicity by pyrazolone compounds, derivatives of tetrahydroindazolonedicarboxylic acid (HIDA)


Filipović Marijić, Vlatka; Makarević, Janja; Stojković, Ranko; Kalinić, Lidija; Katalenić, Darinka; Radačić, Marko
Reduction of cisplatin-induced nephrotoxicity by pyrazolone compounds, derivatives of tetrahydroindazolonedicarboxylic acid (HIDA) // Methods and Findings in Experimental and Clinical Pharmacology, 30 (2008), 9; 675-680 (međunarodna recenzija, članak, znanstveni)


Naslov
Reduction of cisplatin-induced nephrotoxicity by pyrazolone compounds, derivatives of tetrahydroindazolonedicarboxylic acid (HIDA)

Autori
Filipović Marijić, Vlatka ; Makarević, Janja ; Stojković, Ranko ; Kalinić, Lidija ; Katalenić, Darinka ; Radačić, Marko

Izvornik
Methods and Findings in Experimental and Clinical Pharmacology (0379-0355) 30 (2008), 9; 675-680

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cisplatin; nephrotoxicity; pyrazolone derivatives of tetrahydroindazolonedicarboxylic acid (HIDA); blood urea nitrogen

Sažetak
The structural requirements relevant for protective efficacy against cisplatin-induced renal toxicity was studied for seven newly synthesized pyrazolone compounds. Since tetrahydroindazolonedicarboxylic acid (HIDA) has shown potential nephroprotective efficacy, our study involved HIDA derivatives with specific modifications of functional groups. Pyrazolone compounds comprised four types of structural modifications: an HIDA regioisomer derivative (compound 1), compounds with modifications at the pyrazolone ring (compounds 2, 3 and 4) or the dicarboxylic moiety (compounds 5 and 6), and a compound without a cyclohexane moiety (compound 7). The best nephroprotective efficacy was found for compound 1, as reflected in the lowering of cisplatin-induced levels of blood urea nitrogen (BUN) by 86.3-89.3%, depending on cisplatin administration time. The alicyclic pyrazolonedicarboxylic acid (compound 7), characterized by free rotation of attached moieties due to the lack of a cyclohexane moiety, also showed good protection (lowering of cisplatin-induced BUN levels by 29.5-81.7%, depending on cisplatin administration time). Lower nephroprotective activity was found for compounds 2 and 3, with N- and O-substituted pyrazolone rings, and for the cyano derivative 5, while compounds without a carboxylic and pyrazolone moiety (compounds 6 and 4, respectively) did not show a nephroprotective effect. Therefore, carboxylic and pyrazolone moieties play an important role in the interaction with cisplatin and represent relevant functional groups required for nephroprotective efficacy in pyrazolone compounds.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2390 - Novi terapijski modaliteti u liječenju malignih bolesti (Ranko Stojković, )
098-0982904-2912 - Samo-udruživanje u gelovima i sinteza funkcionalnih hibridnih materijala (Leo Frkanec, )
098-0982934-2721 - Stanične promjene u vodnih organizama pobuđene metalima (Marijana Erk, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE