engleski

A novel type of unsaturated seconucleoside analogues

1′, 2′-Unsaturated secoadenosine 3–6 and secouridine 15, 16 analogues were synthesized by the base promoted regioselective elimination of corresponding 2′, 3′-ditosylates. Efficient and selective O-detritylation of these acid sensitive compounds was achieved by ZnBr2 in dichloromethane.

nucleoside analogs ; selective protection ; oxidation ; regioselective elimination

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