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Pregled bibliografske jedinice broj: 329888

Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT


Staneloudi, Chrysovalanto; Smith, Karen A.; Hudson, Robert; Pesa, Nela; Savoie, Huguettte; Boyle, Ross W.; Greenman, John
Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT // 10th World Congress of the International Photodynamic Association
Minhen, Njemačka, 2005. (poster, nije recenziran, neobjavljeni rad, znanstveni)


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Naslov
Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT

Autori
Staneloudi, Chrysovalanto ; Smith, Karen A. ; Hudson, Robert ; Pesa, Nela ; Savoie, Huguettte ; Boyle, Ross W. ; Greenman, John

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
10th World Congress of the International Photodynamic Association

Mjesto i datum
Minhen, Njemačka, 22-25.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Photodynamic therapy; scFv; Phage display; Porphyrin; Bioconjugation

Sažetak
An expression system giving high yield of scFv fragments has been established. The molar ratios at which the conjugation to scFv was carried out has been optimized. These immunoconjugates showed low levels of non-covalently associated porphyrin, minimizing potential non-specific cytotoxicity. Based on these findings, together with preliminary data using immunoconjugates of scFv raised against freshly-isolated tumour cells, we suggest that scFv:poprhyrin conjugates may show promise for use as an antibody-targeted photodynamic strategy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Sveučilište u Osijeku - Odjel za kemiju

Profili:

Avatar Url Nela Malatesti (autor)


Citiraj ovu publikaciju:

Staneloudi, Chrysovalanto; Smith, Karen A.; Hudson, Robert; Pesa, Nela; Savoie, Huguettte; Boyle, Ross W.; Greenman, John
Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT // 10th World Congress of the International Photodynamic Association
Minhen, Njemačka, 2005. (poster, nije recenziran, neobjavljeni rad, znanstveni)
Staneloudi, C., Smith, K., Hudson, R., Pesa, N., Savoie, H., Boyle, R. & Greenman, J. (2005) Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT. U: 10th World Congress of the International Photodynamic Association.
@article{article, year = {2005}, keywords = {Photodynamic therapy, scFv, Phage display, Porphyrin, Bioconjugation}, title = {Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT}, keyword = {Photodynamic therapy, scFv, Phage display, Porphyrin, Bioconjugation}, publisherplace = {Minhen, Njema\v{c}ka} }
@article{article, year = {2005}, keywords = {Photodynamic therapy, scFv, Phage display, Porphyrin, Bioconjugation}, title = {Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT}, keyword = {Photodynamic therapy, scFv, Phage display, Porphyrin, Bioconjugation}, publisherplace = {Minhen, Njema\v{c}ka} }




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