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Pregled bibliografske jedinice broj: 329868

Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers


Peša, Nela; Smith, Karen A.; Savoie, Huguette; Greenman, John; Boyle, Ross W.
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers // Book of Abstracts
Aix-les-Bains, Francuska, 2005. (poster, nije recenziran, sažetak, znanstveni)


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Naslov
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers

Autori
Peša, Nela ; Smith, Karen A. ; Savoie, Huguette ; Greenman, John ; Boyle, Ross W.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2005

Skup
11th Congress of the European Society for Photobiology (ESP)

Mjesto i datum
Aix-les-Bains, Francuska, 03-08.09.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Photodynamic therapy; Porphyrin; Monoclonal antibodies; Bioconjugation

Sažetak
Four cationic isothiocyanato diphenyl and one tetraphenyl porphyrins were synthesised. Their bioconjugation to several Mabs was successfully carried out without compromising the binding of the antibodies. Cytotoxicity assays and the LD50’ s show that the porphyrin conjugates were more photocytotoxic than free porphyrin. Porphyrin 4 caused cell death through the rapid onset of apoptosis probably due to its mitochondrial localisation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Sveučilište u Osijeku - Odjel za kemiju

Profili:

Avatar Url Nela Malatesti (autor)


Citiraj ovu publikaciju:

Peša, Nela; Smith, Karen A.; Savoie, Huguette; Greenman, John; Boyle, Ross W.
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers // Book of Abstracts
Aix-les-Bains, Francuska, 2005. (poster, nije recenziran, sažetak, znanstveni)
Peša, N., Smith, K., Savoie, H., Greenman, J. & Boyle, R. (2005) Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers. U: Book of Abstracts.
@article{article, year = {2005}, keywords = {Photodynamic therapy, Porphyrin, Monoclonal antibodies, Bioconjugation}, title = {Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers}, keyword = {Photodynamic therapy, Porphyrin, Monoclonal antibodies, Bioconjugation}, publisherplace = {Aix-les-Bains, Francuska} }
@article{article, year = {2005}, keywords = {Photodynamic therapy, Porphyrin, Monoclonal antibodies, Bioconjugation}, title = {Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers}, keyword = {Photodynamic therapy, Porphyrin, Monoclonal antibodies, Bioconjugation}, publisherplace = {Aix-les-Bains, Francuska} }




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