Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers (CROSBI ID 534485)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Peša, Nela ; Smith, Karen A. ; Savoie, Huguette ; Greenman, John ; Boyle, Ross W.
engleski
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers
Four cationic isothiocyanato diphenyl and one tetraphenyl porphyrins were synthesised. Their bioconjugation to several Mabs was successfully carried out without compromising the binding of the antibodies. Cytotoxicity assays and the LD50’ s show that the porphyrin conjugates were more photocytotoxic than free porphyrin. Porphyrin 4 caused cell death through the rapid onset of apoptosis probably due to its mitochondrial localisation.
Photodynamic therapy; Porphyrin; Monoclonal antibodies; Bioconjugation
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Podaci o prilogu
2005.
objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts
Podaci o skupu
11th Congress of the European Society for Photobiology (ESP)
poster
03.09.2005-08.09.2005
Aix-les-Bains, Francuska