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Antibiotic resistance mechanisms in bacteria: biochemical and genetic aspects (CROSBI ID 138210)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Džidić, Senka ; Šušković, Jagoda ; Kos, Blaženka Antibiotic resistance mechanisms in bacteria: biochemical and genetic aspects // Food technology and biotechnology, 46 (2008), 1; 11-21

Podaci o odgovornosti

Džidić, Senka ; Šušković, Jagoda ; Kos, Blaženka

engleski

Antibiotic resistance mechanisms in bacteria: biochemical and genetic aspects

Since the discovery and subsequent widespread use of antibiotics, a variety of bacterial species of human and animal origin have developed numerous mechanisms that render bacteria resistant to some, and in certain cases to nearly all antibiotics. There are many important pathogens that are resistant to multiple antibiotic classes, and infections caused by multidrug resistant (MDR) organisms are limiting treatment options and compromising effective therapy. So the emergence of antibiotic resistant pathogens in bacterial populations is a relevant field of study in molecular and evolutionary biology and in medical practice. There are two main aspects to the biology of antimicrobial resistance. One is concerned with the development, acquisition and spread of the resistance gene itself. The other is the specific biochemical mechanism conveyed by this resistance gene. In this review we present some recent data on molecular mechanisms of antibiotic resistance.

antibiotic resistance; multidrug resistance; antibiotic inactivation; target modification; drug efflux; membrane permeability changes hypermutators; horizontal gene transfe

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Podaci o izdanju

46 (1)

2008.

11-21

objavljeno

1330-9862

Povezanost rada

Biotehnologija

Indeksiranost