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Chronic renal failure deranges non-specific cellular immunity


Čala, Svjetlana; Kordić, Darka; Varlaj-Knobloch, Vesna; Janković, Nikola
Chronic renal failure deranges non-specific cellular immunity // Periodicum Biologorum, 102 (2000), 1; 109-111 (međunarodna recenzija, kratko priopcenje, znanstveni)


Naslov
Chronic renal failure deranges non-specific cellular immunity

Autori
Čala, Svjetlana ; Kordić, Darka ; Varlaj-Knobloch, Vesna ; Janković, Nikola

Izvornik
Periodicum Biologorum (0031-5362) 102 (2000), 1; 109-111

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
phagocytosis; monocytes; neutrophils; TNF-α; Il-1α; large granular lymphocytes; uremia; hemodialysis; CAPD

Sažetak
To find out if frequent infections in chronic renal failure patients are accompanied by defects in non-specific immunity, particularly of monocyte and polymorphonuclear phagocytic function and large granular lymphocyte number. Monocite and neutrophil phagocytosis of non-opsonized yeast cells, production of cytokines TNF-&#945; and Il-1&#945; by endotoxin stimulated monocyte cultures, and number of LGL in the peripheral blood were analysed in 15 uremic patients on conservative treatment (U), 18 hemodialysis patients (HD), and 9 patients treated by continuous ambulatory peritoneal dialysis (CAPD). Uremia decreased monocyte ingestion (0.78 vs. 1.07 yeast cells retained per phagocyte ; p = 0.003), neutrophil ingestion (2.46 vs. 3.15 ; p = 0.003), neutrophil digestion (5 vs. 9% of killed among ingested yeast cells ; p<0.001), and LGL number (46 vs. 164 x 106/L ; p<0.036), while increase in TNF-&#945; (2.0 vs. 1.3 ng/mL) and Il-1&#945; (1.7 vs. 1.4 ng/mL) synthesis was not significant. HD ameliorate all parameters, the only significant reductions left were neutrophil digestion (5.5 vs. 9% ; p = 0.002), and LGL number (109 vs. 164 x 106/L ; p = 0.0001). Values for CAPD group were not statistically different from uremia. Renal insufficiency causes the failure of non-specific cellular immunity that is not completely corrected by dialytic treatment and, together with increased exposure, contributes to increased infection frequency.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0134011

Ustanove
KBC "Sestre Milosrdnice"

Citiraj ovu publikaciju

Čala, Svjetlana; Kordić, Darka; Varlaj-Knobloch, Vesna; Janković, Nikola
Chronic renal failure deranges non-specific cellular immunity // Periodicum Biologorum, 102 (2000), 1; 109-111 (međunarodna recenzija, kratko priopcenje, znanstveni)
Čala, S., Kordić, D., Varlaj-Knobloch, V. & Janković, N. (2000) Chronic renal failure deranges non-specific cellular immunity. Periodicum Biologorum, 102 (1), 109-111.
@article{article, year = {2000}, pages = {109-111}, keywords = {phagocytosis, monocytes, neutrophils, TNF- and \#945, , Il-1 and \#945, , large granular lymphocytes, uremia, hemodialysis, CAPD}, journal = {Periodicum Biologorum}, volume = {102}, number = {1}, issn = {0031-5362}, title = {Chronic renal failure deranges non-specific cellular immunity}, keyword = {phagocytosis, monocytes, neutrophils, TNF- and \#945, , Il-1 and \#945, , large granular lymphocytes, uremia, hemodialysis, CAPD} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus