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Pregled bibliografske jedinice broj: 329499

Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers


Malatesti, Nela; Smith, Karen; Savoie, Huguette; Greenman, John; Boyle, Ross W.
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers // International Journal of Oncology, 28 (2006), 6; 1561-1569 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 329499 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers

Autori
Malatesti, Nela ; Smith, Karen ; Savoie, Huguette ; Greenman, John ; Boyle, Ross W.

Izvornik
International Journal of Oncology (1019-6439) 28 (2006), 6; 1561-1569

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Photodynamic therapy; Monoclonal antibodies; Porphyrins

Sažetak
The synthesis of three cationic 5, 15-diphenyl porphyrins, bearing an isothiocyanate group for conjugation to proteins is described. The potential of these compounds as targeted photosensitisers for use in photodynamic therapy (PDT) is demonstrated by their efficient conjugation to monoclonal antibodies and the ability of the bioconjugates to bind and photodynamically inactivate cancer cells that express the corresponding antigen.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Sveučilište u Osijeku - Odjel za kemiju

Profili:

Avatar Url Nela Malatesti (autor)

Citiraj ovu publikaciju:

Malatesti, Nela; Smith, Karen; Savoie, Huguette; Greenman, John; Boyle, Ross W.
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers // International Journal of Oncology, 28 (2006), 6; 1561-1569 (međunarodna recenzija, članak, znanstveni)
Malatesti, N., Smith, K., Savoie, H., Greenman, J. & Boyle, R. (2006) Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers. International Journal of Oncology, 28 (6), 1561-1569.
@article{article, year = {2006}, pages = {1561-1569}, keywords = {Photodynamic therapy, Monoclonal antibodies, Porphyrins}, journal = {International Journal of Oncology}, volume = {28}, number = {6}, issn = {1019-6439}, title = {Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers}, keyword = {Photodynamic therapy, Monoclonal antibodies, Porphyrins} }
@article{article, year = {2006}, pages = {1561-1569}, keywords = {Photodynamic therapy, Monoclonal antibodies, Porphyrins}, journal = {International Journal of Oncology}, volume = {28}, number = {6}, issn = {1019-6439}, title = {Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers}, keyword = {Photodynamic therapy, Monoclonal antibodies, Porphyrins} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • MEDLINE
  • Scisearch
  • Cambridge Scientific Abstracts
  • Current Awareness in Biological Sciences





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