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Pregled bibliografske jedinice broj: 328479

Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia


Boban, Marina; Grbić, Kristina; Mladinov, Mihovil; Hof, Patrick R; Süssmair, C; Ackl, Nibal; Stanić, Gabrijela; Bader, Benedikt; Danek, Adrian; Šimić, Goran
Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia // Collegium Antropologicum, 32 (2008), S1; 31-36 (međunarodna recenzija, članak, znanstveni)


Naslov
Cerebrospinal fluid markers in differential diagnosis of Alzheimer's disease and vascular dementia

Autori
Boban, Marina ; Grbić, Kristina ; Mladinov, Mihovil ; Hof, Patrick R ; Süssmair, C ; Ackl, Nibal ; Stanić, Gabrijela ; Bader, Benedikt ; Danek, Adrian ; Šimić, Goran

Izvornik
Collegium Antropologicum (0350-6134) 32 (2008), S1; 31-36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer's disease; cerebrospinal fluid; ELISA; phosphorylated epitopes; tau proteins; vascular dementia

Sažetak
Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common causes of dementia in old people. They remain difficult to differentiate in practice because of lack of sensitivity and specificity of current clinical diagnostic criteria. Recent molecular and cellular advancements indicate that the use of cerebrospinal fluid markers may improve early detection and differential diagnosis of AD. Our objective in this study was to determine diagnostic accuracy of three cerebrospinal (CSF) markers: total tau protein (t-tau), tau protein phosphorylated on threonine 181 (p-tau181) and tau protein phosphorylated on serine 199 (wp-tau199). Using commercially available ELISA kits concentrations of t-tau, p-tau181 and p-tau199 were analyzed in 12 patients with probable AD, 9 patients with VaD and 12 NC subjects. The median levels of all three markers were significantly higher in AD group versus VaD and NC groups. However, when the sensitivity levels were set to 85% or higher, only t-tau and p-tau199 satisfied consensus recommendations (specificity more than 75%) when differentiating AD from VaD. In conclusion, our preliminary data on a small group of selected subjects suggest that the CSF t-tau and p-tau199 levels are useful markers for differentiating AD from VaD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Abstracts in Anthropology
  • Anthropological Literature
  • Arts and Humanities Search
  • MEDLINE
  • Sociological Abstracts