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Pregled bibliografske jedinice broj: 327264

Evolution of the clinical presentation and outcomes after radical prostatectomy for patients with clinically localized prostate cancer--changing trends over a ten year period


Štimac, Goran; Dimanovski, Jordan; Trnski, Davor; Katušić Josip; Ružić, Boris; Spajić, Branko; Reljić, Ante; Padovan, Milko; Kraus, Ognjen
Evolution of the clinical presentation and outcomes after radical prostatectomy for patients with clinically localized prostate cancer--changing trends over a ten year period // Collegium Antropologicum, 31 (2007), 4; 1055-1060 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 327264 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Evolution of the clinical presentation and outcomes after radical prostatectomy for patients with clinically localized prostate cancer--changing trends over a ten year period

Autori
Štimac, Goran ; Dimanovski, Jordan ; Trnski, Davor ; Katušić Josip ; Ružić, Boris ; Spajić, Branko ; Reljić, Ante ; Padovan, Milko ; Kraus, Ognjen

Izvornik
Collegium Antropologicum (0350-6134) 31 (2007), 4; 1055-1060

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
radical prostatectomy; outcomes; localized prostate cancer; time trends

Sažetak
We demonstrate the evolution of the clinical presentation and outcomes for patients with clinically localized prostate cancer (PC) treated with radical retropubic prostatectomy (RRP) at our department, emphasizing epidemiologic significance of changes during the 10-year period. We assessed the annual trends for changes in patients age, preoperative prostate specific antigen (PSA), preoperative versus postoperative stages and Gleason grades, organ confined status and surgical margin status. A total of 488 RRPs were performed from January 1996 to December 2005 with the annual frequency increased from 8 to 129 (1512.5%). Mean patient age increased from 61.5 to 66.12 years in 2005, with the percentage of men aged more than 70 years increased from 12.5 to 26.5%, respectively. The detection of PC based solely on pathological PSA levels (as indication for prostate biopsy) rose impressively from 25.5 to 70% and the rates of postoperative organ-confined disease also increased significantly from 25 to 74.7%. Mean preoperative PSA decreased from 16.7 to 9.89 ng/mL. On the contrary, there was an increase in percentage of patients with preoperative PSA values ranging from 4 to 10 ng/mL (from 20 to 65.4%). Positive surgical margin rate decreased from 49.4 to 25% and percent of patients receiving neoadjuvant therapy decreased from 78.5 to 5.4%. Proportion of patients who were undergraded decreased from 75.1 to 31.7%. The rates of understaging have remained relatively stable over the years. During the study period, PC was increasingly detected by prostate biopsy on the basis of a pathological PSA level only and shifted significantly to more organ-confined stages with more favourable outcomes for pathological variables due to a more accurate assessment of clinical stage prior to surgery, reduced use of neoadjuvant therapy and improved surgical technique. Our data also argue strongly that routine PSA testing should be expanded and not restricted.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
143-1080002-0050 - Dijagnostika i liječenje bolesnika sa sindromom prostatitisa (Škerk, Višnja, MZOS ) ( POIROT)
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju:

Štimac, Goran; Dimanovski, Jordan; Trnski, Davor; Katušić Josip; Ružić, Boris; Spajić, Branko; Reljić, Ante; Padovan, Milko; Kraus, Ognjen
Evolution of the clinical presentation and outcomes after radical prostatectomy for patients with clinically localized prostate cancer--changing trends over a ten year period // Collegium Antropologicum, 31 (2007), 4; 1055-1060 (međunarodna recenzija, članak, znanstveni)
Štimac, G., Dimanovski, J., Trnski, D., Katušić Josip, Ružić, B., Spajić, B., Reljić, A., Padovan, M. & Kraus, O. (2007) Evolution of the clinical presentation and outcomes after radical prostatectomy for patients with clinically localized prostate cancer--changing trends over a ten year period. Collegium Antropologicum, 31 (4), 1055-1060.
@article{article, author = {\v{S}timac, Goran and Dimanovski, Jordan and Trnski, Davor and Ru\v{z}i\'{c}, Boris and Spaji\'{c}, Branko and Relji\'{c}, Ante and Padovan, Milko and Kraus, Ognjen}, year = {2007}, pages = {1055-1060}, keywords = {radical prostatectomy, outcomes, localized prostate cancer, time trends}, journal = {Collegium Antropologicum}, volume = {31}, number = {4}, issn = {0350-6134}, title = {Evolution of the clinical presentation and outcomes after radical prostatectomy for patients with clinically localized prostate cancer--changing trends over a ten year period}, keyword = {radical prostatectomy, outcomes, localized prostate cancer, time trends} }
@article{article, author = {\v{S}timac, Goran and Dimanovski, Jordan and Trnski, Davor and Ru\v{z}i\'{c}, Boris and Spaji\'{c}, Branko and Relji\'{c}, Ante and Padovan, Milko and Kraus, Ognjen}, year = {2007}, pages = {1055-1060}, keywords = {radical prostatectomy, outcomes, localized prostate cancer, time trends}, journal = {Collegium Antropologicum}, volume = {31}, number = {4}, issn = {0350-6134}, title = {Evolution of the clinical presentation and outcomes after radical prostatectomy for patients with clinically localized prostate cancer--changing trends over a ten year period}, keyword = {radical prostatectomy, outcomes, localized prostate cancer, time trends} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • EMBASE (Excerpta Medica)
  • MEDLINE





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