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Pregled bibliografske jedinice broj: 325795

The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations


Wittine, Karlo; Benci, Krešimir; Rajić, Zrinka; Zorc, Branka; Kralj, Marijeta; Marjanović, Marko; Pavelić, Krešimir; De Clercq, Eric; Andrei, Graciela; Snoeck, Robert et al.
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations // European journal of medicinal chemistry, 44 (2009), 1; 143-151 doi:10.1016/j.ejmech.2008.03.037 (međunarodna recenzija, članak, znanstveni)


Naslov
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations

Autori
Wittine, Karlo ; Benci, Krešimir ; Rajić, Zrinka ; Zorc, Branka ; Kralj, Marijeta ; Marjanović, Marko ; Pavelić, Krešimir ; De Clercq, Eric ; Andrei, Graciela ; Snoeck, Robert ; Balzarini, Jan ; Mintas, Mladen

Izvornik
European journal of medicinal chemistry (0223-5234) 44 (2009), 1; 143-151

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nonsteroidal Anti-Inflammatory Drugs (NSAID); 3-Hydroxypropylamides; Phosphoramidates; Cytostatic Activity

Sažetak
The target phosphoramidates 5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a-e and 5a-e were evaluated for their cytostatic and antiviral activity against malignant tumour cell lines and normal human fibroblasts (WI38). All phosphoramidate derivatives 5a-e possess significantly greater inhibitory activities than the corresponding 3-hydroxypropyl derivatives 3a-e, whereby compound 5a showed the most potent inhibitory activities against cervical, pancreatic and colon carcinoma cell lines (IC50 = 5 7  M).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mladen Mintas, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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