engleski

Pattern of ganglioside expression in central nervous system of Myotis sp. bat

Gangliosides are components of the plasma membrane. They consist of ceramide anchor and different number of sialic acid linked to inner or/and outer galactose sugar core chain (Gluc GalGalNAc Gal). Gangliosides are ten times more abundant in CNS of higher vertebrates then in any of extraneural tissues. Out of almost 100 different types GM1, GD1a, GD1b and GT1b are major forms appearing in CNS. The exact physiological and neurobiological role is still unknown. However there is evidence that they participate in neurogenesis, brain development and maturation, synapse formation, memory, communication and adhesion of cells and information transduction. Physiologically they serve as NGF, EGF, insulin and interferon sensitivity regulators. Pathophysiologically they bind some biotoxins and participate in some cancerous processes. Furthermore there are recent evidences that they participate as CNS homeostatic factors in ectothermic and endothermic animals during hibernation allowing neural functions at low temperatures. Immunohistochemicaly, using monoclonal Ab against GM1, GD1a, GD1b and GT1b, we showed the distribution of gangliosides in CNS of adult Myotis sp. bat. The results are the major starting point for further possible research of hibernation changes, embryonic neurogenesis of pathways evolutionary specific to bats. Also the results could be used as aid and reference in biomedical research since they represent a good evolutionary comparison model to human ganglioside research data.

gangliosides; CNS; bat

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